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Norbuprenorphine and respiratory depression: Exploratory analyses with new lyophilized buprenorphine and sublingual buprenorphine
. | LitMetric

AI Article Synopsis

Article Abstract

Objectives: To investigate plasma levels of buprenorphine and norbuprenorphine and their relationship to respiratory depression.

Materials And Methods: Opioid-dependent subjects were randomized 2 : 1 to novel lyophilized rapid-disintegrating tablet ("bup-lyo") or standard sublingual buprenorphine tablet ("bup-SL"). Measurements included oximetry scores and linked plasma buprenorphine and norbuprenorphine levels.

Results: Respiratory depression (cumulative duration of SpO < 90% over 30-minute periods) increased with corresponding exposure levels (AUC) of buprenorphine and particularly with norbuprenorphine. A lower buprenorphine/norbuprenorphine ratio was predictive of respiratory depression. The mean (SD) observed ratio was significantly higher for "bup-lyo" (3.4 (2.8)) compared to "bup-SL" (1.7 (0.77)), p < 0.0001.

Conclusion: Exploratory investigation found respiratory depression more strongly associated with norbuprenorphine than with buprenorphine. This accords with animal studies.
.

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Source
http://dx.doi.org/10.5414/CP203118DOI Listing

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