Cancer of unknown primary site is a histologically confirmed cancer that manifests in advanced stage, with no identifiable primary site following standard diagnostic procedures. Patients are initially categorized based on the findings of the initial biopsy: adenocarcinoma, squamous-cell carcinoma, neuroendocrine carcinoma, and poorly differentiated carcinoma. Appropriate patient management requires understanding several clinical and pathological features that aid in identifying several subsets of patients with more responsive tumors.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5785607 | PMC |
| http://dx.doi.org/10.1007/s12094-017-1807-y | DOI Listing |
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