AI Article Synopsis
- Seventeen quinazoline alkaloids and their derivatives were isolated from the ethanol extracts of Peganum harmala L. seeds, including two new epimers and a new enantiomer.
- The structures and absolute configurations of these compounds were determined using 1D and 2D NMR, along with ECD calculations.
- Among the isolated compounds, one (number 11) displayed moderate cytotoxicity against PC-3 cancer cells with an IC value of 15.41 μM.
Article Abstract
Seventeen quinazoline alkaloids and derivatives, containing two pairs of new epimers, named as (S)- and (R)-1-(2-aminobenzyl)-3-hydroxypyrrolidin-2-one β-d-glucopyranosyl-(1 → 6)-β-d-glucopyranoside (1, 2), (S)- and (R)-vasicinone β-d-glucopyranosyl-(1 → 6)-β-d-glucopyranoside (3, 4), and a new enantiomer (12b), together with six known ones (5-8, 10, and 12a), and three pairs of known enantiomers (9, 11, and 13), were isolated from the ethanol extracts of the seeds of Peganum harmala L.. Their structures including the absolute configuration were elucidated by using 1D and 2D NMR, and ECD calculation approaches. The cytotoxic activities of all isolated compounds were evaluated. 11 showed moderate cytotoxicity against PC-3 cells with an IC value of 15.41 μM.
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| http://dx.doi.org/10.1016/j.bmcl.2017.12.003 | DOI Listing |
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