Cytomegalovirus (CMV) causes serious complications among solid organ transplant recipients. We report the positive correlation between the presence of the HLA-E*01:03 allele in living-donor kidney recipients and CMV reactivation during the first year after transplantation. Thus, HLA-E genotyping may help identify CMV replication-prone patients who require individualized patient-based CMV management.
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Protective Effect of HLA-Eā0101āā0103 Genotype in Survival of Patients After Allogeneic Hematopoietic Stem Cell Transplant.
Exp Clin Transplant
August 2021
From the Transplant Research Center, Shiraz University of Medical Sciences; and the Islamic Azad University, Arsanjan Branch, Shiraz, Iran.
Objectives: HLA-E is located on the nonclassical major histocompatibility complex class I and acts as the ligand for natural killer cells. Consequently, it has a main role in the regulation of innate immune responses by involving cell identification by natural killer cells. Differences in expression levels among HLA-E alleles have been suggested to affect transplant outcomes.
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