[COMBINED COURSE OF BRONCHIAL ASTHMA AND GASTROESOPHAGEAL REFLUX DISEASE: ITS CLINICAL, FUNCTIONAL PECULIARITIES, AND MECHANISMS OF ITS CORRECTION].

The combined course of bronchial asthma (BA) and digestive system pathology is one of the most frequent, severe and clinically varied pathology. The purpose of the paper - to study the influence of gastroesophageal reflux disease (GERD) on the course of BA and the effectiveness of antireflux therapy in combined pathology. Patients with combined pathology were treated in full-time department more frequently than patients with isolated BA (3,4±0,5 per year to - 1,8±0,3; р<0,05). The statistically reliable correlation between frequency of heartburn and frequency of cough, which goes over to asthma attacks was observed (r=0,59; р<0,05). More severe course of BA was observed in patients with combined pathology and was accompanied by reliable decrease in the main functional indicators of external breathing (FEB). The antireflux therapy lead to decrease in cough intensity and frequency of asthma attacks, especially at night time. Also, as a result of antireflux therapy patients were able to refuse to use short-acting ß2-agonists in 51,7 % and significantly decreased the multiplicity of its reception in "on-demand" mode. In patients with GERD more severe course of BA was observed. The reliable decrease in the main indicators of FEB, activation of inflammatory process (mainly allergic character of inflammation with high level of eosinophils in blood and sputum) and increase in level of IL - 4 in the blood. The frequency of hospitalization in patients with combined BA and GERD was 2 times greater than in patients with isolated BA. The complex therapy using antireflux has positive effect on clinical symptoms, functional indicators of external breathing and markers of inflammation in patients with combined BA and GERD.