Total knee arthroplasty (TKA) is a rewarding procedure in patients with hemophilia and end stage knee hemophilic arthropathy. However, this procedure might be associated with complications such as infection. There periprosthetic joint infection in patients with hemophilia is very well known, though we are not aware of any previous report on Brucella infection in this group of patients. Here, we reported a 28-year old man with Brucella infection of total knee replacement who initially underwent a conservative treatment followed bya two-stage revision. We believe that this report will alert physicians who work in endemic area for brucellosis to consider this in differential diagnosis and do the right intervention at the right time.
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