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Changes in the gut microbiota composition and the plasma ghrelin level in patients with infected patients with eradication therapy. | LitMetric

AI Article Synopsis

  • The study aimed to examine how antimicrobials affect gut microbiota and plasma ghrelin levels in patients undergoing eradication therapy for infection.
  • Twenty patients aged around 68 participated, receiving a week of triple therapy; their stool and blood samples were analyzed before, immediately after, and three months post-treatment.
  • Results showed a significant increase in the Bacteroidetes:Firmicutes ratio and a decrease in active ghrelin levels three months after treatment, suggesting that changes in gut bacteria may influence hormone levels.

Article Abstract

Objective: To investigate the influence of antimicrobials on both the gut microbiota structure and the plasma ghrelin level using -infected patients who underwent eradication therapy.

Design: Twenty -infected patients (mean age 68.3 years old) who underwent eradication therapy participated in the study. For the therapy, patients had 1 week of triple therapy consisting of amoxicillin, clarithromycin and proton-pump inhibitors. Stool and blood samples were obtained before (S1), immediately after (S2) and/or 3 months after (S3) the therapies. The concentrations of ghrelin and leptin in the blood were assayed using an ELISA. The V3-V4 region of the 16S rRNA gene was amplified using bacterial DNA from the stool, and about 50 000 high-quality amplicons per sample were grouped into operational taxonomic units for bacteriological analyses.

Results: The Bacteroidetes:Firmicutes (B:F) ratio was significantly greater at S3 than S1 (P<0.01). This increase in the B:F ratio between S3 and S1 was found in 15 out of 20 patients. A significant decrease in the concentration of active ghrelin (P=0.003) in the plasma was observed between S3 and S1. There was a statistically significant correlation between the rate of patients whose B:F ratio increased and that of patients whose active ghrelin level decreased between S3 and S1 according to Fisher's exact probability test (P=0.03).

Conclusions: Changes in the gut microbiota, such as the B:F ratio after treatment with antimicrobials, might cause a change in the plasma ghrelin level, as the direct and earliest target of antimicrobials would be the microbiota rather than the hormone-secreting system.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5717420PMC
http://dx.doi.org/10.1136/bmjgast-2017-000182DOI Listing

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