A 60-year-old man with a history of hypertension, type 2 diabetes, and reflux esophagitis was admitted to our hospital with hemoptysis, dyspnea, and leg edema. We diagnosed him with adult IgA vasculitis based on the presence of purpura, elevated serum IgA fibronectin complexes, pathophysiological findings, a skin biopsy showing leukocytoclastic vasculitis, and immunofluorescence studies demonstrating granular IgA and C3 deposits in the blood vessel wall. He showed concurrent cardiopulmonary involvement without involvement of the gastrointestinal system and kidneys, which are commonly affected in IgA vasculitis patients. Following treatment with prednisolone, the patient recovered with improvement in cardiopulmonary manifestations.
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http://dx.doi.org/10.2169/internalmedicine.9681-17 | DOI Listing |
J Multidiscip Healthc
January 2025
Department of Rheumatology and Immunology, Wuhan Children's Hospital, Tongji Medical College, Huazhong University of Science &Technology, Wuhan, 430016, People's Republic of China.
Background: Henoch-Schönlein Purpura (HSP) is a common systemic vasculitis in children that often involves the gastrointestinal system (GIS). Identifying reliable predictive markers for GIS complications is crucial for early intervention and improved patient outcomes.
Objective: This study aims to identify laboratory markers predictive of GIS complications in children with HSP using a machine learning approach.
JAAD Case Rep
February 2025
Department of Dermatology, University of New Mexico School of Medicine, Albuquerque, New Mexico.
Biomedicines
January 2025
Discipline of Clinical Laboratory and Food Safety, Faculty of Pharmacy, "Carol Davila" University of Medicine and Pharmacy, 6 Traian Vuia Street, 020945 Bucharest, Romania.
Immunoglobulin A (IgA) vasculitis (IgAV), classically known as Henoch-Schönlein purpura (HSP), is a type of nonthrombocytopenic small-vessel vasculitis. HSP is the most frequent kind of systemic vasculitis in children, characterized by purpura, arthritis or arthralgia, gastrointestinal pain, and kidney dysfunction. The aim of our research was to investigate and observe the clinical characteristics of children diagnosed with HSP and to explore the correlation between infectious diseases and HSP.
View Article and Find Full Text PDFBMC Infect Dis
January 2025
National Clinical Research Center for Child Health, National Children's Regional Medical Center, the Children's Hospital, Zhejiang University School of Medicine, Hangzhou, 310052, China.
Objective: To explore the influence of respiratory infections on the onset of Henoch-Schönlein Purpura (HSP) in children, along with exploring potential underlying mechanisms.
Method: The present study conducted a statistical analysis on renal involvement indicators in 296 children with HSP who came to the Children's Hospital of Zhejiang University, as well as the IgA levels in 400 children with respiratory infections and 400 children with HSP.
Results: Compared with the control group, children with HSP exhibited a significant increase in urine red blood cell count, urine microalbuminuria, and urine protein/creatinine ratio (P < 0.
Urol Case Rep
January 2025
Department of Pediatrics, Al-Ahli Hospital, Hebron, Palestine.
Henoch-Schönlein Purpura (HSP), or IgA vasculitis, is a systemic inflammatory disorder primarily affecting children. While common symptoms include purpura, abdominal pain, and arthritis, testicular involvement is rare. We report a case of a young boy presenting with severe scrotal pain and swelling, later identified as epididymo-orchitis secondary to HSP.
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