Two new carotane-type sesquiterpenes named trichocaranes E (1) and F (2), along with two known ones CAF-603 (3) and trichocarane C (4), were isolated from cultures of the insect pathogenic fungus Isaria fumosorosea. Their structures and relative configurations were elucidated by extensive spectroscopic analysis and X-ray crystallography. Compounds 1-3 showed potent cytotoxic activities against six tumor cell lines MDA, MCF-7, SKOV-3, Hela, A549, HepG2 with IC values in a concentration range of 0.1-6.0 μg/ml.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1080/10286020.2017.1410143 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Filicinic Acid-Based Meroterpenoids with Antiproliferative Activity against Prostate Cancer PC-3 Cells from .
J Org Chem
January 2025
Department of Pharmacy, The First Affiliated Hospital, Jinan University, Guangzhou 510630, China.
Nine new structurally diverse filicinic acid-based meroterpenoids (-) with four kinds of carbon skeletons were isolated from the rhizomes of . Their structures, including the absolute configurations, were elucidated by comprehensive analysis of spectroscopic data, quantum chemical calculations, and single-crystal X-ray diffraction. Structurally, compounds - feature an unprecedented 6/6/5/6/6/6 hexacyclic system with a rare oxaspiro[4.
View Article and Find Full Text PDFExploration of diverse secondary metabolites from Penicillium brasilianum by co-culturing with Armillaria mellea.
Appl Microbiol Biotechnol
September 2024
Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100050, China.
Article Synopsis
- Bioinformatic analysis shows Penicillium spp. genomes may contain numerous uncharacterized biosynthetic gene clusters (BGCs).
- Co-culture fermentation of Armillaria mellea and P. brasilianum led to the discovery of five new compounds, including unique sesquiterpenes and a polyketide, along with seven previously known substances.
- The study highlights the potential of co-culture methods for uncovering new metabolites and proposes a metabolic pathway for newly identified sesquiterpenoids, enhancing the understanding of biosynthesis in these organisms.
Sesquiterpenes from with anti-neuroinflammatory effects.
J Asian Nat Prod Res
January 2024
Key Laboratory of Innovative Traditional Chinese Medicine for Major Chronic Diseases of Liaoning Province, Key Laboratory for TCM Material Basis Study and Innovative Drug Development of Shenyang City, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China.
An anti-neuroinflammatory activities-guided phytochemical research of was performed for the first time. Three undescribed carotane-type sesquiterpenes, excoecafolinols C-E (), and nine known sesquiterpene derivatives were isolated from the effective ethyl acetate extract of . Their structures were determined based on multiple spectroscopic techniques and electronic circular dichroism (ECD) spectra.
View Article and Find Full Text PDFPeniterester, a carotane-type antibacterial sesquiterpene from an artificial mutant Penicillium sp. T2-M20.
Fitoterapia
January 2020
Key Laboratory of Functional Molecules Analysis and Biotransformation of Universities in Yunnan Province, Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, School of Chemical Science and Technology, Yunnan University, Kunming 650091, PR China. Electronic address:
Peniterester (1), a new tricyclic sesquiterpene, together with 6 known compounds (2-7) were isolated from the secondary metabolites of an artificial mutant Penicillium sp. T2-M20 which was obtained from the parental strain Penicillium sp. T2-8 via UV irradiation as well as nitrosoguanidine (NTG) induction.
View Article and Find Full Text PDFCarotane-type sesquiterpenes from cultures of the insect pathogenic fungus Isaria fumosorosea.
J Asian Nat Prod Res
March 2019
a Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of Ministry of Education, College of Life Science , Hebei University, Baoding 071002 , China.
Two new carotane-type sesquiterpenes named trichocaranes E (1) and F (2), along with two known ones CAF-603 (3) and trichocarane C (4), were isolated from cultures of the insect pathogenic fungus Isaria fumosorosea. Their structures and relative configurations were elucidated by extensive spectroscopic analysis and X-ray crystallography. Compounds 1-3 showed potent cytotoxic activities against six tumor cell lines MDA, MCF-7, SKOV-3, Hela, A549, HepG2 with IC values in a concentration range of 0.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!