AI Article Synopsis
- The study examined the link between maternal levels of perfluoroalkyl acids (PFAAs) at delivery and various birth outcomes, as well as the impact of early life exposure on child growth and weight gain.
- Maternal PFAA levels were measured using blood samples taken three weeks post-delivery from mothers in Uppsala County, Sweden, and children's growth data were sourced from medical records.
- The findings revealed that higher maternal levels of certain PFAAs were associated with lower birth weights, while some PFAAs were linked to changes in body mass index (BMI) in children aged 3 to 5 years, indicating potential impacts on fetal and early childhood development.
Article Abstract
We investigated if maternal body burdens of perfluoroalkyl acids (PFAAs) at the time of delivery are associated with birth outcome and if early life exposure (in utero/nursing) is associated with early childhood growth and weight gain. Maternal PFAA body burdens were estimated by analysis of serum samples from mothers living in Uppsala County, Sweden (POPUP), sampled three weeks after delivery between 1996 and 2011. Data on child length and weight were collected from medical records and converted into standard deviation scores (SDS). Multiple linear regression models with appropriate covariates were used to analyze associations between maternal PFAA levels and birth outcomes (n=381). After birth Generalized Least Squares models were used to analyze associations between maternal PFAA and child growth (n=200). Inverse associations were found between maternal levels of perfluorononanoic acid (PFNA), perfluorodecanoic acid (PFDA), and perfluoroundecanoic acid (PFUnDA), and birth weight SDS with a change of -0.10 to -0.18 weight SDS for an inter-quartile range (IQR) increase in ng/g PFAA. After birth, weight and length SDS were not significantly associated with maternal PFAA. However, BMI SDS was significantly associated with PFOA, PFNA, and PFHxS at 3 and 4years of age, and with PFOS at 4 and 5years of age. If causal, these associations suggest that PFAA affects fetal and childhood body development in different directions.
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| http://dx.doi.org/10.1016/j.envint.2017.12.002 | DOI Listing |
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