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Novel compound heterozygous variants in cause a like Dysplastic Optic Disc with macular abnormalities without coexistent microphthalmia or cataract.
Ophthalmic Genet
March 2025
Senior Consultant, Clinical Scientist and International Faculty, Pediatric Ophthalmology and Ocular Genetics, CMER (Shenzhen) Dennis Lam Hospital, Shenzhen, China.
Background: Congenital optic disc dysplasia with coexistent macular abnormalities is seen in Morning-glory disc anomaly, optic disc pit, -related disc coloboma, and in the -related Papillo-renal syndrome. We report novel compound heterozygous variants in causing optic disc dysplasia and macular abnormality without coexisting cataract or microphthalmia for the first time in Chinese ethnicity and also describe the macular OCT findings.
Materials And Methods: A 4 year-8 months-old female child presented with poor vision, photophobia, and nystagmus noticed 4 months after her birth was diagnosed elsewhere to have isolated cone dystrophy.
Visual performance, light distortion and patient reported outcomes with a new bi-aspheric non-diffractive extended depth of focus intraocular lens.
Front Med (Lausanne)
February 2025
Department of Cataract Surgery, Oftalvist Alicante, Alicante, Spain.
Background: To evaluate refractive, visual, and patient-reported outcomes three months after bilateral implantation of a novel bi-aspheric, non-diffractive extended depth of focus (EDOF) intraocular lens (IOL) using PhaseRing technology to achieve good vision across distances with reduced dysphotopsia.
Methods: Twenty-two patients received bilateral Asqelio EDOF IOLs (AST VisionCare Inc.) and were evaluated 3 months post-surgery.
Efficacy of Remote Care in Cataract Surgery: a Systematic Review.
J Cataract Refract Surg
March 2025
University Eye Clinic, Maastricht University Medical Center, The Netherlands.
Topic: To evaluate the efficacy of currently available digital and remote care applications for postoperative cataract management compared to traditional methods for postoperative clinical measurements.
Clinical Relevance: With the increasing demand for ophthalmological services and an anticipated shortage of professionals, innovative approaches are needed to optimize care. Cataract surgery, characterized by its high safety profile and turnover rate, is well-suited for digital and remote care solutions, which could enhance the postoperative patient pathway, potentially leading to substantial time and cost savings.
Supratherapeutic Inhaled Corticosteroid Use in Patients Initiating on Biologic Therapies for Severe Asthma: A Nationwide Cohort Study.
Lung
March 2025
Department of Respiratory Medicine, Copenhagen University Hospital, Bispebjerg, Copenhagen, Denmark.
Background: In severe asthma, intensive ("supratherapeutic") doses of inhaled corticosteroids (ICS) are often used. The prevalence of supratherapeutic ICS use and its impact on corticosteroid-related comorbidities is poorly understood. We aimed to describe the prevalence of supratherapeutic ICS use in severe asthma, its relation to corticosteroid-related comorbidities, and changes in prescribed and redeemed ICS dose after 12 months of biologic therapy.
View Article and Find Full Text PDFMassive iris cyst in an adult female.
Am J Ophthalmol Case Rep
June 2025
Viterbi Family Department of Ophthalmology at the Shiley Eye Institute, University of California San Diego, San Diego, CA, USA.
Purpose: To report an interesting case of a massive iris cyst encompassing nearly the entire anterior chamber in an adult female years after cataract surgery.
Observation: A 77-year-old female with a history of bilateral cataract surgery presented with a large ciliary body mass in the left eye. The lesion was first incidentally noted one year prior to presentation and continued to grow and ultimately caused complete obstruction of the visual axis.
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