Isolation of bastadin-6-O-sulfate and expedient purifications of bastadins-4, -5 and -6 from extracts of Ianthella basta.

Christopher J Gartshore Mariam N Salib August A Renshaw Tadeusz F Molinski

Fitoterapia

Department of Chemistry and Biochemistry, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, 9500 Gilman Drive MC0358, La Jolla, San Diego, CA 92093, United States; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, 9500 Gilman Drive MC0358, La Jolla, San Diego, CA 92093, United States. Electronic address:

Published: April 2018

Bastadin-6-34-O-sulfate ester (8) was isolated from methanol extracts of Ianthella basta. The structure of 8 was characterized by analysis of MS and NMR data, and conversion through acid hydrolysis, to the parent compound, bastadin-6, which was identical by HPLC, MS and NMR with an authentic sample. An improved procedure for procurement of pure samples of bastadins-4 (4), -5 (5) and -6 (6) is described.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6391048	PMC
http://dx.doi.org/10.1016/j.fitote.2017.12.003	DOI Listing

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