A simple geometry is used to compare several of the available Monte Carlo software codes for radiation transport. EGSnrc, Geant4 and MCNP5 are all used to calculate the photon fluence produced from electrons incident on a copper target. Four energies for the isotropic point source are chosen to simulate the average and maximum emission energies of P and Y: (0.7, 1.71)MeV and (0.93, 2.28)MeV, respectively. The energy deposition in the copper target, the electron current at the target and the computational efficiency are also calculated. EGSnrc is found to be the only self-consistent code when comparing results calculated using the default transport parameters of the condensed history mode with those calculated in the single scattering mode.
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http://dx.doi.org/10.1016/j.apradiso.2017.11.023 | DOI Listing |
Environ Pollut
December 2024
Associate Unit CSIC-University of Huelva "Atmospheric Pollution", Center for Research in Sustainable Chemistry - CIQSO, University of Huelva, E21007 Huelva, Spain; Department of Earth Sciences, Faculty of Experimental Sciences, University of Huelva, Campus El Carmen s/n, E21007, Huelva, Spain.
Emissions of metals and metalloids as a result of industrial processes, entail a great risk to human health. A high time resolution study on arsenic levels in PM in the city of Huelva (SW Spain) was carried out between September 2021 and September 2022. Hourly data obtained with a near real-time technique based on X-ray fluorescence were inter-compared with other offline analytical instrumentation.
View Article and Find Full Text PDFInt J Pharm
December 2024
School of Pharmacy, Jiangsu University, Zhenjiang, Jiangsu 212013, PR China. Electronic address:
Alzheimer's disease (AD) is a neurodegenerative disease that is significantly characterized by cognitive and memory impairments, which worsen significantly with age. In the late stages of AD, metal ion disorders and an imbalance of reactive oxygen species (ROS) levels occur in the brain microenvironment, which causes abnormal aggregation of β-amyloid (Aβ), leading to a significant worsening of the AD symptoms. Therefore, we designed a composite nanomaterial of macrophage membranes-encapsulated Prussian blue nanoparticles (PB NPs/MM).
View Article and Find Full Text PDFJ Hazard Mater
December 2024
Institute for Global Food Security, School of Biological Sciences, Queen's University Belfast, Belfast, United Kingdom; Material and Advanced Technologies for Healthcare, Queen's University of Belfast, 18-30 Malone Road, Belfast BT9 5DL, United Kingdom. Electronic address:
Microplastics (MPs) and Nanoplastics (NPs), a burgeoning health hazard, often go unnoticed due to suboptimal analytical tools, making their way inside our bodies through various means. Surface Enhanced Raman Spectroscopy (SERS), although is utilized in detecting NPs, challenges arise at low concentrations due to their low Raman cross section and inability to situate within hotspots owing to their ubiquitous size and shape. This study presents an innovative and cost-effective approach employing household metallic foils (aluminium and copper) as nanoparticle-on-film (NPoF) substrates for targeting such analytes.
View Article and Find Full Text PDFJ Nanobiotechnology
December 2024
Key Laboratory of Emergency and Trauma of Ministry of Education, Engineering Research Center for Hainan Biological Sample Resources of Major Diseases, the Hainan Branch of National Clinical Research Center for Cancer, the First Affiliated Hospital, Hainan Medical University, Haikou, 570102, China.
Limited drug accumulation and an immunosuppressive microenvironment are the major bottlenecks in the treatment of glioblastoma multiforme (GBM). Herein, we report a copper-coordination driven brain-targeting nanoassembly (TCe6@Cu/TP5 NPs) for site-specific delivery of therapeutic agents and efficient immunotherapy by activating the cGAS-STING pathway and downregulating the expression of PD-L1. To achieve this, the mitochondria-targeting triphenylphosphorus (TPP) was linked to photosensitizer Chlorin e6 (Ce6) to form TPP-Ce6 (TCe6), which was then self-assembled with copper ions and thymopentin (TP5) to obtain TCe6@Cu/TP5 NPs.
View Article and Find Full Text PDFDiscov Nano
December 2024
Department of Pharmaceutics, SRM College of Pharmacy, SRM Institute of Science and Technology, Kattankulathur, Tamil Nadu, 603203, India.
Cervical cancer remains a significant health challenge in developing countries are high due to low HPV vaccination rates, delayed diagnosis, and restricted healthcare access. Metal nanomaterials, such as copper oxide (CuO) nanoparticles (NPs), have shown significant promise in cancer therapy due to their ability to induce apoptosis. 5-Fluorouracil (5-Fu) enhances the cytotoxic effect against cervical cancer, working synergistically with CuO NPs to maximize the therapeutic impact while potentially reducing the 5-Fu's systemic side effects.
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