AI Article Synopsis
- Psychosocial stress increases the risk of cardiovascular disease, including effects on vascular aging and regeneration.
- Dipeptidyl peptidase-4 (DPP-4) plays key roles in various physiological processes by regulating important substrates like GLP-1, influencing several health aspects such as oxidative stress and inflammation.
- Recent studies suggest that targeting the imbalance between DPP-4 and GLP-1 could be a promising strategy for treating vascular aging and atherosclerosis in stressed animals.
Article Abstract
Exposure to psychosocial stress is a risk factor for cardiovascular disease, including vascular aging and regeneration. Dipeptidyl peptidase-4 (DPP-4) exerts many physiological and pharmacological functions by regulating its extremely abundant substrates [eg., glucagon-like peptide-1 (GLP-1), stromal cell-derived factor-1α/C-X-C chemokine receptor type-4, etc.]. Over the past decade, emerging data has revealed unexpected roles for DPP-4 and GLP-1 in intracellular signaling, oxidative stress production, lipid metabolism, cell apoptosis, immune activation, insulin resistance, and inflammation. This mini review focuses on recent findings in this field, highlighting an imbalance between DPP4 and GLP-1 as a potential therapeutic target in the management of vascular aging and atherosclerosis in animals under experimental stress conditions.
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| http://dx.doi.org/10.1111/1440-1681.12903 | DOI Listing |
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