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An extensive dataset of spiking activity to reveal the syntax of the ventral stream.

Neuron

January 2025

Department of Vision & Cognition, Netherlands Institute for Neuroscience (KNAW), 1105 BA Amsterdam, the Netherlands; Department of Integrative Neurophysiology, VU University, De Boelelaan 1085, 1081 HV Amsterdam, the Netherlands; Department of Neurosurgery, Academic Medical Centre, Postbus 22660, 1100 DD Amsterdam, the Netherlands; Laboratory of Visual Brain Therapy, Sorbonne Université, INSERM, CNRS, Institut de la Vision, 17 rue Moreau, 75012 Paris, France. Electronic address:

Visual neuroscience benefits from high-quality datasets with neuronal responses to many images. Several neuroimaging datasets have been published in recent years, but no comparable dataset with spiking activity exists. Here, we introduce the THINGS ventral stream spiking dataset (TVSD).

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Individualized Spectral Features in First-episode and Drug-naïve Major Depressive Disorder: Insights from Periodic and Aperiodic EEG Analysis.

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School of Biomedical Sciences and Engineering, South China University of Technology, Guangzhou 511442, China; National Engineering Research Center for Tissue Restoration and Reconstruction, South China University of Technology, Guangzhou 510006, China; Guangdong Province Key Laboratory of Biomedical Engineering, South China University of Technology, Guangzhou 510006, China; Department of Nuclear Medicine and Radiology, Institute of Development, Aging and Cancer, Tohoku University, Sendai 980-8575, Japan. Electronic address:

Background: The detection of abnormal brain activity plays an important role in the early diagnosis and treatment of major depressive disorder (MDD). Recent studies have shown that the decomposition of the electroencephalography (EEG) spectrum into periodic and aperiodic components is useful for identifying the drivers of electrophysiologic abnormalities and avoiding individual differences.

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White matter hyperintensities (WMH) of presumed vascular origin are a magnetic resonance imaging (MRI)-based biomarker of cerebral small vessel disease (CSVD). WMH are associated with cognitive decline and increased risk of stroke and dementia, and are commonly observed in aging, vascular cognitive impairment, and neurodegenerative diseases. The reliable and rapid measurement of WMH in large-scale multisite clinical studies with heterogeneous patient populations remains challenging, where the diversity of imaging characteristics across studies adds additional complexity to this task.

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