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Challenges and perspectives in the management of BRAF-mutated metastatic melanoma: Systemic treatment sequencing and brain metastases.
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Reina Sofía University Hospital, Córdoba, Spain.
The global incidence of metastatic melanoma with BRAF mutations, characterized by aggressive behavior and poor prognosis, is rising. Recent treatment advances, including immune checkpoint inhibitors (ICI) and targeted therapies (TT) such as BRAF and MEK inhibitors, have significantly enhanced patient outcomes. Although guidelines recommend sequencing strategies, real-world implementation can be influenced by clinical scenarios.
View Article and Find Full Text PDFHealth effects of occupational exposure to jet fuels used in the military: A systematic review of the epidemiologic literature.
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ICF, Reston, VA, USA. Electronic address:
Background: Jet fuels are a common chemical exposure in occupational settings involving aircraft. Jet fuels are heterogeneous mixtures of aromatic and aliphatic hydrocarbons, as well as non-hydrocarbon performance additives. Several components of jet fuels have been linked to adverse health outcomes.
View Article and Find Full Text PDFThe Songdo consensus: Development of minimum reporting standards for studies of intervention in idiopathic anal fistula using a modified nominal group technique.
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View Article and Find Full Text PDF[SEFAC 2025 Conference: Community pharmacy facing the challenge of specialisation and change].
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. Coordinador de las Jornadas SEFAC 2025. Vocal de la Junta Directiva de SEFAC. SEFAC España.
In 2025, which marks the 25th anniversary of our scientific society, SEFAC will be celebrating its national conference under the slogan 'Community pharmacy as a health, scientific and specialised profession', which attempts to encapsulate the essence of this period of transformation for the profession. Embracing change is not just an option but a necessity to ensure a solid and recognised future. As part of the 15th Conference, the professional debate 'Speciality in community pharmacy: a necessity?' will be held, which will serve to reflect on the path towards the consolidation of a specialisation that legitimises and further enhances the role of the community pharmacist within the healthcare system.
View Article and Find Full Text PDFThe global prevalence of interstitial lung disease in patients with rheumatoid arthritis: a systematic review and meta-analysis.
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School of Medicine, The University of Western Australia, 35 Stirling Highway, Perth, WA, 6009, Australia.
This study aims to review the literature and estimate the global pooled prevalence of interstitial lung disease among patients with rheumatoid arthritis (RA-ILD). The influence of risk factors like geography, socioeconomic status, smoking and DMARD use will be explored. A systematic review was performed according to the PRISMA and JBI guidelines.
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