The first observation of rf heating in a reversed field pinch (RFP) using the electron Bernstein wave (EBW) is demonstrated on the Madison Symmetric Torus. Propagation across and heating in a stochastic magnetic field is observed. Novel techniques are required to measure the suprathermal electron tail generated by EBW heating in the presence of intense Ohmic heating. rf-heated electrons directly probe the edge transport properties in the RFP; measured loss rates imply a large noncollisional radial diffusivity.
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http://dx.doi.org/10.1103/PhysRevLett.119.185001 | DOI Listing |
Am J Pathol
December 2024
Division of Gastroenterology and Hepatology, Stanford University, Palo Alto, California; Palo Alto VA, Palo Alto, California. Electronic address:
Mitochondrial maladaptation and dysfunction contribute to the progression of metabolic dysfunction-associated steatohepatitis (MASH). The authors recently implicated the induction of Shc in progressive MASH during aging and the cytoplasmic p52Shc isoform in the activation of redox enzyme NOX2. The mitochondrial Shc isoform p46Shc was shown to repress acetyl-coenzyme A acyltransferase 2 (ACAA2) in vitro.
View Article and Find Full Text PDFJ Geophys Res Space Phys
December 2024
Magnetic reconnection has been commonly reported between the solar wind IMF and the magnetic field of Earth and other planets. A similar phenomenon is expected between Jupiter's magnetosphere and Ganymede's mini magnetosphere inside the Jovian magnetosphere. This article is the first report of a reconnection event in the tail region of Ganymede.
View Article and Find Full Text PDFGenetics
January 2025
Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, 720 Rutland Avenue, Baltimore, MD 21205, USA.
Myosin storage myopathy (MSM) is a rare skeletal muscle disorder caused by mutations in the slow muscle/β-cardiac myosin heavy chain (MHC) gene. MSM missense mutations frequently disrupt the tail's stabilizing heptad repeat motif. Disease hallmarks include subsarcolemmal hyaline-like β-MHC aggregates, muscle weakness, and, occasionally, cardiomyopathy.
View Article and Find Full Text PDFPhys Rev E
August 2024
Section for Plasma Physics and Fusion Energy, Department of Physics, Technical University of Denmark, DK-2800 Kgs. Lyngby, Denmark.
The Wentzel, Kramers, and Brillouin (WKB) approximation of geometrical optics is widely used in plasma physics, quantum mechanics, and reduced wave modeling, in general. However, it is well-known that the approximation breaks down at focal and turning points. In this paper, we present an unsupervised numerical implementation of the recently developed metaplectic geometrical optics framework, which extends the applicability of geometrical optics beyond the limitations of WKB, such that the wave field remains finite at caustics.
View Article and Find Full Text PDFFront Ophthalmol (Lausanne)
July 2024
Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA, United States.
Introduction: Macular Telangiectasia type 2 (MacTel), is an uncommon form of late-onset, slowly-progressive macular degeneration. Associated with regional Müller glial cell loss in the retina and the amino acid serine synthesized by Müller cells, the disease is functionally confined to a central retinal region - the MacTel zone.
Methods: We have used high-throughput multi-resolution electron microscopy techniques, optimized for disease analysis, to study the retinas from two women, mother and daughter, aged 79 and 48 years respectively, suffering from MacTel.
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