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Relaxation moduli of glass-forming systems: temperature effects and fluctuations.
Soft Matter
September 2021
Institut Charles Sadron, CNRS - UPR 22, Université de Strasbourg, 23 rue du Loess, BP 84047, 67034 Strasbourg Cedex 2, France.
Equilibrium and dynamical properties of a two-dimensional polydisperse colloidal model system are characterized by means of molecular dynamics (MD) and Monte Carlo (MC) simulations. We employed several methods to prepare quasi-equilibrated systems: in particular, by slow cooling and tempering with MD (method SC-MD), and by tempering with MC dynamics involving swaps of particle diameters (methods Sw-MD, Sw-MC). It is revealed that the Sw-methods are much more efficient for equilibration below the glass transition temperature T leading to denser and more rigid systems which show much slower self-diffusion and shear-stress relaxation than their counterparts prepared with the SC-MD method.
View Article and Find Full Text PDFMetabolism and pharmacokinetics of the anti-tuberculosis drug ethionamide in a flavin-containing monooxygenase null mouse.
Pharmaceuticals (Basel)
November 2013
Department of Environmental and Molecular Toxicology, Oregon State University, 1007 ALS Corvallis, OR 97331, USA; (A.L.P.); (V.L.L.); (A.L.).
Article Synopsis
- The study examines how multiple drug resistance in Mycobacterium tuberculosis leads to an increased reliance on second-line drugs like ethionamide (ETA), which is activated by certain enzymes called flavin-containing monooxygenases (FMOs).
- A specific genetic variation in the FMO2 enzyme affects its activity, influencing how different individuals metabolize ETA; this variation is more common in certain populations, particularly among Africans and Hispanics.
- Results from experiments with mice show that those with normal FMO2 had higher levels of ETA metabolites, indicating better drug metabolism, while genetically modified mice lacking FMO2 produced higher levels of the unmetabolized drug, suggesting that FMO2 genotype could affect treatment outcomes for tuberculosis.
Extended acoustic modes in random systems with n-mer short range correlations.
J Phys Condens Matter
August 2011
Instituto de Física, Universidade Federal de Alagoas, Maceió-AL 57072-970, Brazil.
In this paper we study the propagation of acoustic waves in a one-dimensional medium with a short range correlated elasticity distribution. In order to generate local correlations we consider a disordered binary distribution in which the effective elastic constants can take on only two values, η(A) and η(B). We add an additional constraint that the η(A) values appear only in finite segments of length n.
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