AI Article Synopsis
- Long noncoding RNAs (lncRNAs) are found to be expressed abnormally in the cartilage of people with osteoarthritis (OA).
- These lncRNAs can either promote or inhibit OA by interacting with various biological targets, affecting key processes in the condition.
- The review focuses on the role of lncRNAs in the health of cartilage cells, factors related to arthritis, blood vessel formation, and their potential uses in diagnosing and treating OA.
Article Abstract
It is reported that long noncoding RNAs (lncRNAs) were expressed aberrantly in cartilage of osteoarthritis (OA). Current evidence indicates that lncRNAs not only serve as positive or negative regulators of OA, but also crosstalk with multiple potential targets to impact on the critical events in OA process. This review summarized the lncRNAs identified in OA to date, discussed their influence on the survival of chondrocytes and synoviocytes, arthritis-associated factors, and angiogenesis, and indicated the potential in diagnosis, therapy, and prognosis.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5714763 | PMC |
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