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| http://dx.doi.org/10.4103/ija.IJA_363_17 | DOI Listing |
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Inhalable tobramycin EEG powder formulation for treating Pseudomonas aeruginosa-induced lung infection.
Int J Pharm
September 2024
Department of Pharmaceutics, Virginia Commonwealth University, Richmond, VA, USA; Department of Ophthalmology, Massey Cancer Center, Center for Pharmaceutical Engineering, and Institute for Structural Biology, Drug Discovery & Development (ISB3D), Virginia Commonwealth University, Richmond, VA, USA. Electronic address:
Pulmonary delivery of antibiotics is an effective strategy in treating bacterial lung infection for cystic fibrosis patients, by achieving high local drug concentrations and reducing overall systemic exposure compared to systemic administration. However, the inherent anatomical lung defense mechanisms, formulation characteristics, and drug-device combination determine the treatment efficacy of the aerosol delivery approach. In this study, we prepared a new tobramycin (Tobi) dry powder aerosol using excipient enhanced growth (EEG) technology and evaluated the in vitro and in vivo aerosol performance.
View Article and Find Full Text PDFSuccessful Application of Transnasal Humidified Rapid-Insufflation Ventilatory Exchange in a Case of Subglottic Stenosis.
Cureus
April 2024
Anesthesiology and Critical Care, Unidade Local de Saúde de Santo António, Porto, PRT.
We widely employ microlaryngeal surgery to treat diverse oropharyngeal and laryngeal conditions, but it presents challenges to shared airway management. This case report addresses the limitations of conventional techniques, such as tracheal intubation and jet ventilation, and explores the emerging interest in transnasal humidified rapid insufflation ventilatory exchange (THRIVE). While THRIVE offers advantages such as enhanced visualization and reduced airway trauma, its application is limited by the duration of apnea, with the literature referring to a maximum of 30 minutes of apnea.
View Article and Find Full Text PDFSurgical Management of Airway Stenosis During Pregnancy: A Scoping Review.
Laryngoscope
March 2024
Cleveland Clinic, Head & Neck Institute, Cleveland, Ohio, U.S.A.
Objective: There are several options for surgical management of subglottic stenosis, including endoscopic and open procedures. However, treatment algorithms, outcomes, and anesthetic management of subglottic stenosis during pregnancy are not well described.
Data Sources: MEDLINE, EMBASE, and the Cochrane databases.
The Tritube: Facilitating Upper Airway Surgery With an Ultrathin Cuffed Airway Device.
A A Pract
July 2023
From the Department of Anesthesiology, Antwerp University Hospital, Edegem, Belgium.
The Tritube is a narrow-bore cuffed tracheal tube (outer diameter 4.4 mm and inner diameter ~2.4 mm) that permits effective alveolar gas exchange using flow-controlled ventilation.
View Article and Find Full Text PDFAdvancement of a high-dose infant air-jet dry powder inhaler (DPI) with passive cyclic loading: Performance tuning for different formulations.
Int J Pharm
August 2023
Department of Mechanical and Nuclear Engineering, Virginia Commonwealth University, 401 W Main Street, PO Box 843015, Richmond, VA 23284, USA; Department of Pharmaceutics, Virginia Commonwealth University, 410 N. 12th Street, PO Box 980533, Richmond, VA 23284, USA. Electronic address:
There is a current medical need for a dry powder aerosol delivery device that can be used to efficiently and consistently administer high dose therapeutics, such as inhaled antibiotics, surfactants and antivirals, to the lungs of infants. This study considered an infant air-jet dry powder inhaler (DPI) that could be actuated multiple times with minimal user interaction (i.e.
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