Varied factors, whether intrinsic or extrinsic, may lead to a decrease in the bone volume of the jaws. Trauma and pathology can be listed as examples of such factors. The aim of this study is to present the osteogenic distraction technique as alternative to augmentation of low mandibular bone volume caused by different etiologies. The first case reports a mandibular marginal resection of ameloblastoma and the second one reports a male patient presenting mandibular fracture sequelae. Both cases were treated according to the osteogenic distraction technique. Several factors have influence on the decision of treatment management of these conditions. Although autogenous bonegraft is considered criterion standard for alveolar reconstruction, its high rates of resorption and the morbidity associated to donor sites lead surgeons to seek for other surgical alternatives such as osteogenic distraction. Therefore, it also aims to expose the advantages and benefits of this technique as well as the satisfactory results achieved.

Download full-text PDF

Source
http://dx.doi.org/10.1097/SCS.0000000000004215DOI Listing

Publication Analysis

Top Keywords

osteogenic distraction
16
bone volume
8
distraction technique
8
mandibular
4
mandibular reconstruction
4
osteogenic
4
reconstruction osteogenic
4
distraction
4
distraction injuries
4
injuries varied
4

Similar Publications

Article Synopsis
  • The prolonged use of external fixation during distraction osteogenesis (DO) can heighten complications, while bone marrow mesenchymal stem cells (BMSCs) play a crucial role in bone regeneration due to their pro-angiogenic and osteogenic abilities.
  • RSC-96, a type of Schwann cell, has been shown to promote the proliferation, migration, and differentiation of BMSCs when co-cultured, enhancing both bone formation and blood vessel development through neurotrophic factor secretion and activation of specific signaling pathways.
  • In a rat DO model, RSC-96's conditioned medium improved bone healing outcomes, with notable increases in gene expression markers for osteogenesis and angiogenesis, alongside positive radiological and biomechanical assessments.
View Article and Find Full Text PDF

A rat model for microimplant-assisted rapid palatal expansion.

Biochem Biophys Res Commun

December 2024

Department of Orthodontics, State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, National Center for Stomatology, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China. Electronic address:

Background: Microimplant-assisted rapid palatal expansion (MARPE) has been widely used to correct maxillary transverse deficiency. To gain valuable insights into the biological processes and mechanisms involved in palatal suture expansion and develop approaches to reduce relapse rates, researchers have turned to animal models. However, no small-animal models are currently available for MARPE.

View Article and Find Full Text PDF

Uniaxial static strain enhances osteogenic and angiogenic potential under hypoxic conditions in distraction osteogenesis.

J Orthop Surg Res

November 2024

Department of Oral and Maxillofacial Surgery, Stomatological Hospital, School of Stomatology, Southern Medical University, S366 Jiangnan Boulevard,Haizhu District, Guangzhou City, Guangdong Province, China.

Objective: Bone incision leads to interrupted and sluggish blood flow in the process of distraction osteogenesis (DO), creating a hypoxia (0-2% oxygen tension) at the center of the bone callus. This hypoxia is critical in the coupling of osteogenesis and angiogenesis during DO. This study aimed to investigate the effect of Uniaxial Static Strain (USS) on osteogenesis in osteoblasts under hypoxic conditions, with a focus on the expression of osteogenic markers and angiogenic factors.

View Article and Find Full Text PDF

RhoA/ROCK-TAZ Axis regulates bone formation within calvarial trans-sutural distraction osteogenesis.

Cell Signal

September 2024

Department of Orthodontics, The Affiliated Stomatological Hospital of Nanjing Medical University, Nanjing 210029, China; Jiangsu Province Key Laboratory of Oral Diseases, Nanjing Medical University, Nanjing 210029, China; Jiangsu Province Engineering Research Center of Stomatological Translational Medicine, Nanjing Medical University, Nanjing 210029, China; The Fourth Affiliated Hospital of Soochow University, Medical Center of Soochow University, Suzhou 215000, China. Electronic address:

Background: Craniofacial skeletal deformities can be addressed by applying tensile force to sutures to prompt sutural bone formation. The intricate process of mechanical modulation in craniofacial sutures involves complex biomechanical signal transduction. The small GTPase Ras homolog gene family member A (RhoA) functions as a key mechanotransduction protein, orchestrating the dynamic assembly of the cytoskeleton by activating the Rho-associated coiled-coil containing protein kinase (ROCK).

View Article and Find Full Text PDF

Background: Trans-sutural distraction osteogenesis (TSDO) involves the application of distraction force to facial sutures to stimulate osteogenesis. Gli1 cells in the cranial sutures play an important role in bone growth. However, whether Gli1 cells in facial sutures differentiate into bone under distraction force is unknown.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!