A practical, electrochemical method is developed for the direct dehydrogenative lactonization of C(sp/sp)-H bonds under external oxidant- and metal-free conditions, delivering diverse lactones, including coumarin derivatives with excellent regioselectivity. The scalable nature of this newly developed electrochemical process was demonstrated on a 40 g scale following an operationally simple protocol. The remote lactonization of C(sp)-H bonds would constitute an important synthetic advance toward electrochemical C-O bond formation.
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| http://dx.doi.org/10.1021/acs.orglett.7b03617 | DOI Listing |
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