AI Article Synopsis
- The increasing prevalence of non-alcoholic fatty liver disease (NAFLD) in adults and children highlights the need for a non-invasive diagnostic method to accurately assess progression to non-alcoholic steatohepatitis (NASH).
- Current imaging technologies can only detect fat in the liver, making them inadequate for diagnosing NASH, while liver biopsies are invasive and carry risks.
- A new technique using in vivo dynamic nuclear polarization-magnetic resonance imaging can accurately diagnose NASH by monitoring early mitochondrial metabolic changes, presenting a promising alternative to biopsies.
Article Abstract
Given the rising incidence of non-alcoholic fatty liver disease (NAFLD) in both adults and children, the development of a non-invasive diagnostic method for assessing disease progression to non-alcoholic steatohepatitis (NASH) has become an important research goal. Currently available non-invasive imaging technologies are only able to assess fat accumulation in the liver. Therefore, these methods are not suitable for a precise diagnosis of NASH. The standard diagnostic technique for NASH, liver biopsy, has several drawbacks, including the higher risk of complications that accompanies invasive procedures. Here, we demonstrated that in vivo mitochondrial redox metabolism was dramatically altered at an early stage, before histopathological changes, and NASH could be accurately diagnosed by in vivo dynamic nuclear polarization-magnetic resonance imaging, with carbamoyl-PROXYL as a molecular imaging probe. In addition, this technique was feasible for the diagnosis of NASH compared with histopathological findings from biopsies. Our data reveal a novel method for monitoring the dynamics of redox metabolic changes in NAFLD/NASH.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5719423 | PMC |
| http://dx.doi.org/10.1038/s41598-017-17447-2 | DOI Listing |
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