AI Article Synopsis

  • Neural mapping across individuals can be difficult when spatial relationships differ, leading researchers to use functional registration based on responses to specific reference stimuli.
  • The study focused on Drosophila flies, recording their receptor neuron responses to various volatile compounds.
  • The proposed method can advance the creation of reliable biological sensors, utilizing the natural sensitivity of olfactory receptors for better physiological measurements.

Article Abstract

Neural activity can be mapped across individuals using brain atlases, but when spatial relationships are not equal, these techniques collapse. We map activity across individuals using functional registration, based on physiological responses to predetermined reference stimuli. Data from several individuals are integrated into a common multidimensional stimulus space, where dimensionality and axes are defined by these reference stimuli. We used this technique to discriminate volatile compounds with a cohort of Drosophila flies, by recording odor responses in receptor neurons on the flies' antennae. We propose this technique for the development of reliable biological sensors when activity raw data cannot be calibrated. In particular, this technique will be useful for evaluating physiological measurements in natural chemosensory systems, and therefore will allow to exploit the sensitivity and selectivity of olfactory receptors present in the animal kingdom for analytical purposes.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5719416PMC
http://dx.doi.org/10.1038/s41598-017-16913-1DOI Listing

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