The complexity of the pathological reactions of the brain to an aggression caused by an internal or external noxa represents a challenge for molecular imaging. Positron emission tomography (PET) can indicate anatomopathological changes involved in the development of different clinical symptoms in patients with neurodegenerative disorders. PET and the multitracer concept can provide information from different systems in the brain tissue building an image of the whole disease. We present here the combination of F-flourodeoxyglucose (FDG) and N-[C-methyl]-L-deuterodeprenyl (DED), FDG and N-[C-methyl] 2-(4'-methylaminophenyl)-6-hydroxybenzothiazole (PIB), PIB and L-[C]-3'4-Dihydrophenylalanine (DOPA) and finally PIB and [O]H2O.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5619316 | PMC |
| http://dx.doi.org/10.1590/1980-57642015DN94000343 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Self-supervised parametric map estimation for multiplexed PET with a deep image prior.
Phys Med Biol
January 2025
The Division of Imaging Sciences and Biomedical Engineering, King's College London, 5th Floor Becket House, London, SE1 7EH, UNITED KINGDOM OF GREAT BRITAIN AND NORTHERN IRELAND.
Multiplexed positron emission tomography (mPET) imaging allows simultaneous observation of physiological and pathological information from multiple tracers in a single PET scan. Although supervised deep learning has demonstrated superior performance in mPET image separation compared to purely model-based methods, acquiring large amounts of paired single-tracer data and multi-tracer data for training poses a practical challenge and needs extended scan durations for patients. In addition, the generalisation ability of the supervised learning framework is a concern, as the patient being scanned and their tracer kinetics may potentially fall outside the training distribution.
View Article and Find Full Text PDFMultitracer PET/CT Findings in a Case of Behavioral Variant Frontotemporal Dementia With Parkinsonism.
Clin Nucl Med
February 2025
From the Departments of Neurology.
We report the clinical and multimodal PET/CT manifestations in a patient with behavioral variant frontotemporal dementia and parkinsonism. The 18 F-FDG PET scan revealed hypometabolism in the left supratentorial cortex. The 18 F-fluorodopa PET scan demonstrated decreased uptake in the bilateral striatum, most prominent in the head of caudate nucleus.
View Article and Find Full Text PDFAssessment of the relationship between synaptic density and metabotropic glutamate receptors in early Alzheimer's disease: a multi-tracer PET study.
bioRxiv
September 2024
Alzheimer's Disease Research Unit, Yale University School of Medicine, New Haven, CT, USA.
Article Synopsis
- The study investigates the relationship between metabotropic glutamate receptor subtype 5 (mGluR5) and synaptic density in early Alzheimer's disease (AD) using PET imaging techniques.
- Findings reveal a strong positive correlation between mGluR5 levels and synaptic density in the hippocampus and entorhinal cortex of Alzheimer’s patients, but less significant in cognitively normal individuals.
- The research concludes that loss of mGluR5 in the medial temporal lobe is linked to synaptic loss, suggesting its potential role in AD pathology.
Evolving SPECT-CT technology.
Br J Radiol
October 2024
Department of Nuclear Medicine, Royal North Shore Hospital, Sydney, NSW, 2065, Australia.
Both hardware and software developments have seen single photon emission computed tomography (SPECT)/X-ray computed tomography (CT) technology grow at a rapid rate. Such growth has been fuelled by the need for clinical applications and has provided inspiration for clinical developments, particularly with the expanding role of theranostics. Developments such as whole-body quantitative reconstructions, digital detectors, and recent multidetector 3D geometry have allowed SPECT to become comparable to PET on a number of fronts, with a particularly powerful role in biodistribution and dosimetry studies for both planning and evaluating radionuclide therapy.
View Article and Find Full Text PDFDeep learned triple-tracer multiplexed PET myocardial image separation.
Front Nucl Med
April 2024
School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom.
Introduction: In multiplexed positron emission tomography (mPET) imaging, physiological and pathological information from different radiotracers can be observed simultaneously in a single dynamic PET scan. The separation of mPET signals within a single PET scan is challenging due to the fact that the PET scanner measures the sum of the PET signals of all the tracers. The conventional multi-tracer compartment modeling (MTCM) method requires staggered injections and assumes that the arterial input functions (AIFs) of each tracer are known.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!