AI Article Synopsis
- Semaphorins play a key role in guiding axon repulsion during development, but they're also important in the immune system as 'immune semaphorins' that regulate immune cell functions.
- These immune semaphorins influence immune cell activation, differentiation, mobility, and migration, contributing to various autoimmune diseases such as rheumatoid arthritis and systemic lupus erythematosus.
- The review explores how immune semaphorins are involved in disease mechanisms and their potential as diagnostic markers and therapeutic targets for autoimmune disorders.
Article Abstract
Semaphorins have a well-characterized role in guiding axon repulsion during development; however, the important contribution of these proteins in immunity is becoming increasingly clear. Immunoregulatory semaphorins, termed 'immune semaphorins', have roles in regulating immune cell activation, differentiation, mobility and migration. These proteins are also intimately associated with the pathogenesis of autoimmune diseases including rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), systemic sclerosis (SSc) and anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). This Review discusses the pathogenic functions of immune semaphorins, as well as the potential use of these molecules as diagnostic markers and therapeutic targets for the treatment of autoimmune diseases.
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| http://dx.doi.org/10.1038/nrrheum.2017.201 | DOI Listing |
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