AI Article Synopsis
- The study investigates how often older psychiatric patients in Asia are prescribed both benzodiazepines and antidepressants, finding that 44.3% of them receive this combination.
- The research analyzes data from 955 older adults with psychiatric disorders, looking into various demographic and clinical factors that influence co-prescription rates.
- Key factors associated with increased co-prescription include higher antidepressant doses, younger age (under 65), being an inpatient, treatment in public hospitals, having significant medical comorbidities, and specific types of antidepressants and countries.
Article Abstract
Unlabelled: ABSTRACTBackground:Little is known about the combined use of benzodiazepines and antidepressants in older psychiatric patients. This study examined the prescription pattern of concurrent benzodiazepines in older adults treated with antidepressants in Asia, and explored its demographic and clinical correlates.
Methods: The data of 955 older adults with any type of psychiatric disorders were extracted from the database of the Research on Asian Psychotropic Prescription Patterns for Antidepressants (REAP-AD) project. Demographic and clinical characteristics were recorded using a standardized protocol and data collection procedure. Both univariate and multiple logistic regression analyses were performed.
Results: The proportion of benzodiazepine and antidepressant combination in this cohort was 44.3%. Multiple logistic regression analysis revealed that higher doses of antidepressants, younger age (<65 years), inpatients, public hospital, major comorbid medical conditions, antidepressant types, and country/territory were significantly associated with more frequent co-prescription of benzodiazepines and antidepressants.
Conclusions: Nearly, half of the older adults treated with antidepressants in Asia are prescribed concurrent benzodiazepines. Given the potentially adverse effects of benzodiazepines, the rationale of benzodiazepines and antidepressants co-prescription needs to be revisited.
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| http://dx.doi.org/10.1017/S1041610217002563 | DOI Listing |
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