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Mass Spectrometry-Based Identification of Phospho-Tyr in Plant Proteomics.
J Proteome Res
February 2020
Division of Biochemistry , University of Missouri, Columbia , Missouri 65211 , United States.
O-Phosphorylation (phosphorylation of the hydroxyl-group of S, T, and Y residues) is among the first described and most thoroughly studied posttranslational modification (PTM). Y-Phosphorylation, catalyzed by Y-kinases, is a key step in both signal transduction and regulation of enzymatic activity in mammalian systems. Canonical Y-kinase sequences are absent from plant genomes/kinomes, often leading to the assumption that plant cells lack -phospho-l-tyrosine (pY).
View Article and Find Full Text PDFPlazomicin Retains Antibiotic Activity against Most Aminoglycoside Modifying Enzymes.
ACS Infect Dis
June 2018
M.G. DeGroote Institute for Infectious Disease Research, Department of Biochemistry and Biomedical Sciences, DeGroote School of Medicine , McMaster University, 1280 Main Street West , Hamilton , Ontario L8N 4K1 , Canada.
Plazomicin is a next-generation, semisynthetic aminoglycoside antibiotic currently under development for the treatment of infections due to multidrug-resistant Enterobacteriaceae. The compound was designed by chemical modification of the natural product sisomicin to provide protection from common aminoglycoside modifying enzymes that chemically alter these drugs via N-acetylation, O-adenylylation, or O-phosphorylation. In this study, plazomicin was profiled against a panel of isogenic strains of Escherichia coli individually expressing twenty-one aminoglycoside resistance enzymes.
View Article and Find Full Text PDFUnraveling the B. pseudomallei Heptokinase WcbL: From Structure to Drug Discovery.
Chem Biol
December 2015
Department of Biosciences, University of Exeter, Henry Wellcome Building, Stocker Road, Exeter EX4 4QD, UK. Electronic address:
Gram-negative bacteria utilize heptoses as part of their repertoire of extracellular polysaccharide virulence determinants. Disruption of heptose biosynthesis offers an attractive target for novel antimicrobials. A critical step in the synthesis of heptoses is their 1-O phosphorylation, mediated by kinases such as HldE or WcbL.
View Article and Find Full Text PDFIn silico analysis of protein Lys-N(𝜀)-acetylation in plants.
Front Plant Sci
August 2014
Division of Biochemistry, University of Missouri Columbia, MO, USA ; Interdisciplinary Plant Group, University of Missouri Columbia, MO, USA ; Plant Genetics Research Unit, United States Department of Agriculture - Agricultural Research Service Columbia, MO, USA.
Among post-translational modifications, there are some conceptual similarities between Lys-N(𝜀)-acetylation and Ser/Thr/Tyr O-phosphorylation. Herein we present a bioinformatics-based overview of reversible protein Lys-acetylation, including some comparisons with reversible protein phosphorylation. The study of Lys-acetylation of plant proteins has lagged behind studies of mammalian and microbial cells; 1000s of acetylation sites have been identified in mammalian proteins compared with only hundreds of sites in plant proteins.
View Article and Find Full Text PDFChemical detoxification of small molecules by Caenorhabditis elegans.
ACS Chem Biol
February 2013
Department of Biochemistry and Molecular Biology, University of Florida, Gainesville, Florida, USA.
Caenorhabditis elegans lives in compost and decaying fruit, eats bacteria and is exposed to pathogenic microbes. We show that C. elegans is able to modify diverse microbial small-molecule toxins via both O- and N-glucosylation as well as unusual 3'-O-phosphorylation of the resulting glucosides.
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