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Ubiquitin Specific Peptidase 22 Regulates Histone H2B Mono-Ubiquitination and Exhibits Both Oncogenic and Tumor Suppressor Roles in Cancer. | LitMetric

Ubiquitin-Specific Peptidase 22 (USP22) is a ubiquitin hydrolase, notably catalyzing the removal of the mono-ubiquitin moiety from histone H2B (H2Bub1). Frequent overexpression of has been observed in various cancer types and is associated with poor patient prognosis. Multiple mechanisms have been identified to explain how overexpression contributes to cancer progression, and thus, USP22 has been proposed as a novel drug target in cancer. However, gene re-sequencing data from numerous cancer types show that expression is frequently diminished, suggesting it may also harbor tumor suppressor-like properties. This review will examine the current state of knowledge on expression in cancers, describe its impact on H2Bub1 abundance and present the mechanisms through which altered expression may contribute to oncogenesis, including an emerging role for USP22 in the maintenance of genome stability in cancer. Clarifying the impact aberrant expression and abnormal H2Bub1 levels have in oncogenesis is critical before precision medicine therapies can be developed that either directly target overexpression or exploit the loss of expression in cancer cells.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5742815PMC
http://dx.doi.org/10.3390/cancers9120167DOI Listing

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