Objective: The aim of this study was to investigate the therapeutic effect of stretching combined with ultrashort wave on joint contracture and explore its possible mechanism.
Design: Thirty-two rabbits underwent unilateral immobilization of a knee joint at full extension to cause joint contracture. At 6 wks after immobilization, the rabbits were randomly divided into the following four groups: natural recovery group, stretching treatment group, ultrashort wave treatment group, and combined treatment group. For comparison, eight control group animals of corresponding age were also examined. The effect of stretching and ultrashort wave treatment on joint contracture was assessed by measuring the joint range of motion, evaluating the collagen deposition of joint capsule and assessing the mRNA and protein levels for transforming growth factor β1 in the joint capsule.
Results: The combined treatment group led to the best recovery of joint function. The combined treatment with stretching and ultrashort wave was more effective than stretching or ultrashort wave treatment alone against the synovial thickening of suprapatellar joint capsule, the collagen deposition of anterior joint capsule, and the elevated expression of transforming growth factor β1 in the joint capsule.
Conclusions: Stretching combined with ultrashort wave treatment was effective in improving joint range of motion, reducing the biomechanical, histological, and molecular manifestations of joint capsule fibrosis in a rabbit model of extending joint contracture.
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http://dx.doi.org/10.1097/PHM.0000000000000873 | DOI Listing |
Sci Adv
January 2025
Center for Nano Science and Technology, Fondazione Istituto Italiano di Tecnologia, Milano, Italy.
Achieving highly tailored control over both the spatial and temporal evolution of light's orbital angular momentum (OAM) on ultrafast timescales remains a critical challenge in photonics. Here, we introduce a method to modulate the OAM of light on a femtosecond scale by engineering a space-time coupling in ultrashort pulses. By linking azimuthal position with time, we implement an azimuthally varying Fourier transformation to dynamically alter light's spatial distribution in a fixed transverse plane.
View Article and Find Full Text PDFLight Sci Appl
January 2025
Russell Centre for Advanced Lightwave Science, Shanghai Institute of Optics and Fine Mechanics and Hangzhou Institute of Optics and Fine Mechanics, Chinese Academy of Sciences, Shanghai, 201800, China.
Continuous-wave mode-locking at multi-GHz repetition rates is achieved in an ultrashort laser cavity at critical pulse energies 100 times lower than predicted by conventional theory. The authors reveal that dynamic gain depletion and recovery between consecutive round-trips is the key factor behind a low-pulse-energy transition from Q-switched mode-locking (QSML) to continuous-wave mode-locking (CWML). As well as providing new insight into gain dynamics, the results suggest a practical route to low-threshold lasing at very high-repetition rates.
View Article and Find Full Text PDFUltrasonics
November 2024
Department of Condensed Matter and Materials Physics, S. N. Bose National Centre for Basic Sciences, Block JD, Sector III, Salt Lake, Kolkata 700 106, India. Electronic address:
Surface acoustic waves have emerged as one of the potential candidates for the development of next-generation wave-based information and computing technologies. For practical devices, it is essential to develop the excitation techniques for different types of surface acoustic waves, especially at higher microwave frequencies, and to tailor their frequency versus wave vector characteristics. We show that this can be done by using ultrashort laser pulses incident on the surface of a multilayer decorated with a periodic array of metallic nanodots.
View Article and Find Full Text PDFRev Sci Instrum
December 2024
LaserLaB, Department of Physics and Astronomy, Vrije Universiteit Amsterdam, De Boelelaan 1105, 1081HV Amsterdam, The Netherlands.
We present a simple and easy-to-implement Graphics Processing Unit (GPU)-accelerated routine to numerically simulate the propagation of ultrashort and intense laser pulses as they interact with a medium. The routine is based on the solution of Maxwell's wave equation in the frequency domain with an extended Crank-Nicolson algorithm implemented in the Nvidia CUDA C++ programming language. The main advantages of our method are its significant speed-up factor and its ease of implementation, requiring only basic knowledge of CUDA and C++.
View Article and Find Full Text PDFPhys Rev Lett
November 2024
Nantes Université, CNRS, CEISAM, UMR 6230, F-44000 Nantes, France.
Ultrashort pulses can excite or ionize molecules and populate coherent electronic wave packets, inducing complex dynamics. In this Letter, we simulate the coupled electron-nuclear dynamics upon ionization to different electronic wave packets of (deuterated) benzene and fluoro-benzene molecules, quantum mechanically and in full dimensionality. In fluoro-benzene, the calculations unravel both interstate and intrastate quantum interferences that leave clear signatures of attochemistry and charge-directed dynamics in the shape of the autocorrelation function.
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