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Comparison of vasopressors for management of hypotension in high-risk caesarean section under neuraxial anesthesia: a systematic review and network meta-analysis.
BMC Anesthesiol
December 2024
Department of Anesthesiology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Article Synopsis
- Vasopressors like ephedrine, noradrenaline, and phenylephrine are used to manage hypotension during Caesarean sections in high-risk pregnant women receiving neuraxial anesthesia, but the best option is still being researched.
- In a study analyzing 13 trials with 1,262 patients, it was found that while no significant differences were noted in hypotension episodes among the vasopressors, phenylephrine was ranked as the most effective in preventing hypotension.
- Additionally, those on phenylephrine experienced higher rates of bradycardia, but lower instances of nausea and vomiting compared to those on ephedrine, with no major differences in fetal outcomes between noradrenaline and phenylephrine.
Bispectral Index-Monitored Anesthesia Induction in Older Adults Undergoing Elective Surgery: Comparing Ciprofol and Propofol in a Prospective, Single-Center, Double-Blind, Randomized Controlled Study.
Drug Des Devel Ther
November 2024
Department of Anesthesiology, Jiangxi Provincial People's Hospital, The First Affiliated Hospital of Nanchang Medical College, Nanchang, Jiangxi, 330006, People's Republic of China.
Article Synopsis
- Ciprofol is a new sedative anesthetic that shows promise for older adults, particularly in reducing hypotension during anesthesia induction compared to propofol.
- In a study of 117 older adults, ciprofol resulted in a lower incidence of hypotension (26.3%) compared to propofol (48.3%).
- Patients receiving ciprofol also reported less injection pain and maintained stable blood pressure levels while achieving successful anesthesia induction in both groups.
Effect of intravenous palonosetron on hypotension induced by spinal anesthesia for cesarean section: A randomized controlled trial.
PLoS One
June 2024
Department of Anesthesiology and Pain Medicine, College of Medicine, Chung-Ang University, Seoul, South Korea.
Background: The aim of this study was to evaluate the impact of intravenous palonosetron compared to ondansetron on hypotension induced by spinal anesthesia in women undergoing cesarean section.
Methods: Fifty-four women scheduled for elective cesarean section were, randomly allocated to ondansetron group (n = 27) or palonosetron group (n = 27). Ten minutes prior to the administration of spinal anesthesia, participants received an intravenous injection of either ondansetron or palonosetron.
The impact of pre-rehydration guided by carotid corrected flow time on hypotension prevention following general anesthesia induction in patients undergoing gastrointestinal surgery: a prospective randomized controlled trial.
Front Med (Lausanne)
May 2024
Department of Anesthesiology, Chongqing University Cancer Hospital, Chongqing, China.
Background: Patients undergoing gastrointestinal surgery often experience hypotension following general anesthesia induction due to insufficient volume. This study aimed to assess whether pre-rehydration guided by carotid corrected flow time (FTc) could mitigate post-induction hypotension induced by general anesthesia.
Methods: Patients undergoing resection of gastrointestinal tumors were assigned to either the conventional treatment group (Group C) or the fluid treatment group based on FTc (Group F).
Genetic polymorphisms in ADRB1, ADRB2 and CYP2D6 genes and response to beta-blockers in patients with acute coronary syndrome.
Biomed Pharmacother
December 2023
Pharmacy Department, Instituto de Investigación Biosanitaria de Granada (ibs.Granada), Hospital Universitario Virgen de las Nieves, Granada, Spain. Electronic address:
Betablockers (BBs) are prescribed for ischaemia in patients with acute coronary syndrome (ACS). In Spain, bisoprolol and carvedilol are the most prescribed BBs, but patients often had to discontinue them due to adverse effects. Single nucleotide polymorphisms (SNPs) in ADRB1, ADRB2 and CYP2D6 genes have strong evidence of pharmacogenetic association with BBs in heart failure or hypertension, but the evidence in ACS is limited.
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