AI Article Synopsis
- VPS34 is a class III PI 3-kinase that plays a crucial role in cargo sorting and membrane trafficking during endocytosis and in the formation of autophagosomes.
- Researchers utilized an integrative structural biology approach to study VPS34, focusing on its complex structures and the way it interacts with membranes.
- The study aimed to uncover how the activity of VPS34 is regulated and how its conformational dynamics contribute to its functions in cellular processes.
Article Abstract
The class III PI 3-kinase, VPS34 forms distinct complexes essential for cargo sorting and membrane trafficking in endocytosis as well as for autophagosome nucleation and maturation. We used integrative structural biology approach to provide insights into the conformational dynamics of the complex and mechanisms that regulate VPS34 activity at the membrane.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5706946 | PMC |
| http://dx.doi.org/10.1080/23723556.2017.1367873 | DOI Listing |
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