The ETO2-GLIS2 fusion oncoprotein is associated with poor prognosis pediatric acute megakaryoblastic leukemia. Recently, we observed that ETO2-GLIS2 controls enhancers activity at genes regulating haematopoietic progenitor self-renewal and differentiation toward the megakaryocytic lineage. We also showed that targeting ETO2-GLIS2 complex stability inhibits these properties and may represent a novel therapeutic strategy.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5706939 | PMC |
| http://dx.doi.org/10.1080/23723556.2017.1345351 | DOI Listing |
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