Discovering Novel Succinate Dehydrogenase Inhibitors by Modeling and Virtual Screening Strategies to Combat Early Blight.

blight is an important foliage disease caused by . The enzyme Succinate dehydrogenase (SDH) is a potential drug target because of its role in tricarboxylic acid cycle. Hence targeting SDH enzyme could be efficient tool to design novel fungicides against . We employed computational methodologies to design new SDH inhibitors using homology modeling; pharmacophore modeling and structure based virtual screening. The three dimensional SDH model showed good stereo-chemical and structural properties. Based on virtual screening results twelve commercially available compounds were purchased and tested and . The compounds were found to inhibit mycelial growth of . Moreover trials showed that inhibitory effects were enhanced with increase in concentrations. Similarly increased disease control was observed in pre-treated potato tubers. Hence the applied strategy led us to identify novel fungicides.