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Integrating collecting systems in kidney organoids through fusion of distal nephron to ureteric bud.
bioRxiv
September 2024
Division of Nephrology and Hypertension, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
The kidney maintains homeostasis through an array of parallel nephrons, which all originate in development as isolated epithelial structures that later fuse through their distal poles to a system of collecting ducts (CD). This connection is required to generate functional nephrons by providing a pathway for excretion of metabolic waste and byproducts. Currently, methods for differentiating human pluripotent stem cells into kidney organoids generate nephrons that lack CDs and instead terminate as blind-ended tubules.
View Article and Find Full Text PDFUnlabelled: Normal kidney development requires the coordinated interactions between multiple progenitor cell lineages. Among these, Foxd1+ stromal progenitors are essential for nephrogenesis, giving rise to diverse cell types including the renal stroma, capsule, mesangial cells, renin cells, pericytes, and vascular smooth muscle cells (VSMCs). However, the molecular mechanisms governing their differentiation remain poorly understood.
View Article and Find Full Text PDFNephrogenic adenomas are benign lesions that develop within the urinary tract. Most often developing within the urinary bladder, these lesions have a debatable etiopathogenesis, with hamartoma, rest hyperplasia, and transplantation of renal tubular cells being the most widely accepted ones. Nephrogenic adenomas develop more often in adult males, and predisposing factors for their development are prior urinary system injury, infection, or malignancy, with a subset of cases developing in renal transplant patients.
View Article and Find Full Text PDFAcute post-renal kidney graft dysfunction due to cytomegalovirus-positive nephrogenic adenoma-case report and review of the literature.
Front Med (Lausanne)
May 2024
Department of Nephrology and Hypertension, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Tissue-invasive cytomegalovirus (CMV) disease represents a well-recognized complication after kidney transplantation. However, direct involvement of the urogenital tract and CMV-ureteritis occur less frequently. Nephrogenic adenomas are benign lesions of the urinary tract preferentially reported in kidney transplant recipients.
View Article and Find Full Text PDFNoninvasive Diagnosis of Kidney Dysfunction Using a Small-Molecule Manganese-Based Magnetic Resonance Imaging Probe.
Anal Chem
February 2024
School of Medical Imaging, Tianjin Medical University, Tianjin 300203, China.
Article Synopsis
- Contrast-enhanced magnetic resonance imaging (CE-MRI) shows promise for diagnosing kidney diseases but is limited by safety concerns related to gadolinium-based contrast agents (GBCAs) in patients with kidney issues.
- A new manganese-based imaging probe, Mn-PhDTA, has been developed as a safer alternative to GBCAs, showing good stability and biocompatibility.
- In studies with rats, Mn-PhDTA effectively enhanced MR signals, distinguishing between healthy and damaged kidneys, and evaluating kidney function at various stages of injury.
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