AI Article Synopsis
- Monocytes are attracted to areas of chronic inflammation, but the specific molecules responsible for this process are not completely understood.
- The cytokine IL-4 increases the expression of the transcription factor FoxQ1 in human monocytes and macrophages, with heightened levels of FoxQ1 found in monocytes from patients with atopic dermatitis (AD).
- Overexpressing FoxQ1 in monocytic cells enhances their movement towards MCP-1, boosts their inflammatory response, and may play a role in the worsening of chronic inflammatory conditions like AD.
Article Abstract
Monocytes are actively recruited at sites of chronic inflammation. However, molecular factors involved in this process are not fully elucidated. Here, we show that cytokine IL-4 which is implicated in the development of chronic inflammatory disease atopic dermatitis (AD) induces expression of transcription factor FoxQ1 in human monocytes and macrophages. FoxQ1 mRNA levels were elevated in monocytes of AD patients compared to healthy donors. Overexpression of FoxQ1 in RAW 264.7 monocytic cells facilitated their migration towards MCP-1 and was associated with decreased expression of migration-regulating genes (claudin 11 and plexin C1). Furthermore, FoxQ1 overexpression in RAW cells accelerated TNFα secretion after LPS challenge. Overall, our results indicate that FoxQ1 stimulates monocyte motility, increases pro-inflammatory potential, and directs monocyte migration towards MCP-1 that is crucial for monocyte influx into inflammatory sites. This mechanism could contribute to the pathogenesis of chronic inflammatory disorders such as AD.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5715145 | PMC |
| http://dx.doi.org/10.1038/s41598-017-17307-z | DOI Listing |
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