AI Article Synopsis
- - The study investigated the impact of a carbohydrate-rich diet on the bladder muscle (detrusor contractility) in rats, comparing a control group on a regular diet and a study group on a high-carb diet for six weeks.
- - Results showed that rats on the carbohydrate-rich diet gained more weight and had reduced contractile responses in the detrusor muscle, as well as significant fibrosis (scarring) in the bladder compared to the control group.
- - The findings suggest that a high-carb diet adversely affects bladder function and introduces complications that may require costly treatments, advocating for a reduction in carbohydrate intake as a preventative measure.
Article Abstract
Objectives: We aimed to investigate the effect of a carbohydrate-rich diet on detrusor contractility in rats.
Materials And Methods: Sprague-Dawley rats were randomized into two groups. The control group received regular food and water. The study group received carbohydrate-rich diet for six weeks. The rats' detrusor muscle was isolated for pharmacological and histopathological examinations.
Results: In the control and study groups, mean body weights were 431.5 ± 27.6 g and 528.0 ± 36.2 g, respectively ( < 0.001). Electrical stimulation of the detrusor strips of the control group resulted in gradual contraction. A decreased contractile response was shown in the study group. Acetylcholine in 10-7-10-3 molar concentration produced a decreased contractile response in the study group, compared to the control group ( < 0.01). The study group showed marked subepithelial and intermuscular fibrosis in the bladder.
Conclusion: Carbohydrate-rich diet causes marked subepithelial and extracellular fibrosis and changes in contractility in the detrusor within a six-week period. Changes have higher costs in therapeutic choices and correction of these changes remains difficult. Putting an end to carbohydrate-rich diet would seem to be more cost-effective than dealing with the effects of consuming it in high proportions which should be the national policy worldwide.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5671679 | PMC |
| http://dx.doi.org/10.1155/2017/5796456 | DOI Listing |
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