College of Animal Science and Technology, Yangzhou University, Yangzhou, Jiangsu, China.
Published: November 2017
AI Article Synopsis
Article Abstract
Diarrhea is a syndrome of digestive disorders in young rabbits and may lead to secondary infections resulting in reduced immunity and higher mortality in baby rabbits, with serious impacts on rabbit farming. In this study, we investigated the effects of diarrhea on the health of baby rabbits in terms of intestinal mucosal development, immune function, and intestinal microbial diversity. We found that the duodenal villus length and the villus/crypt ratio in rabbits with diarrhea were significantly reduced compared with those in healthy rabbits ( < 0.01). Rabbits with diarrhea had significantly lower concentrations of acetic acid ( < 0.05), higher pH levels ( < 0.05), and higher levels of ammonia nitrogen ( < 0.01) in the cecum. Moreover, diarrhea in baby rabbits led to significantly reduced levels of total serum protein ( < 0.05) and markedly increased levels of alkaline phosphatase, urea nitrogen, TNF-, and IL-6 ( < 0.05). Transcriptional analysis of peptidoglycan recognition proteins (PGRPs, including , , and ) using real-time PCR revealed that diarrhea induced the upregulation of PGRPs in the cecum and duodenum. Furthermore, through pyrosequencing of the 16S rRNA V4 region in cecum samples, we found that the total number and diversity of microbes were not significantly different between healthy rabbits and those with diarrhea, though there were noticeable differences in the prevalences of , and . Our results will contribute to a better understanding of the pathological mechanisms of diarrhea in young rabbits.
The differences between the high-starch diet commonly used in rabbit farming and the natural feeding habits of rabbits may pose certain health risks. In our study, we replaced part of the starch in the feed with soybean oil and conducted a four-week feeding trial with weaned Rex rabbits. The results indicated that rabbits fed the oil-supplemented diet had a lower incidence of diarrhea, improved growth performance, and higher feed conversion efficiency, along with increased absorptive capacity of small intestine.
Early weaning in rabbits often leads to increased diarrhea and mortality, negatively impacting their performance.
A study showed that supplementing lactating female rabbits with probiotics significantly improved milk yield, immune function, and overall growth in their offspring compared to a control group.
The findings suggest probiotics are a beneficial alternative to antibiotics for enhancing rabbit health, but the small sample size may limit the results' reliability, indicating a need for further research.
Diarrhea is the second leading cause of death in children under five years of age globally. Traditional medicinal practices often use plants to manage gastrointestinal issues. Ammodaucus leucotrichus is a medicinal plant that holds significant importance in Moroccan traditional medicine for treating gastrointestinal problems.
Background/aim: This study aims to explore the role of NF-kB p65/p50 expression in patients with inflammatory bowel disease (IBD), those with irritable bowel syndrome (IBS) and normal controls.
Patients And Methods: Twenty patients with IBS, 19 subjects with IBD and 18 normal controls, who underwent colonoscopy, provided us with biopsies from the terminal ileum, cecum and rectum. Patients with IBS were categorized according to bowel habits.
This report presents a rare case of acute bacterial native valve endocarditis caused by in a 57-year-old male with a history of intravenous drug use. The patient presented with chest pain, productive cough, and diarrhea, with clinical evaluation revealing atrial flutter, pulmonary embolism, and a large tricuspid valve vegetation. Blood cultures confirmed , an organism rarely implicated in human infections.
