AI Article Synopsis
- Telocytes are specialized cells found in human uterine leiomyoma (ULM) and adjacent tissues, and they were characterized using advanced techniques like immunohistochemistry and electron microscopy.
- Higher numbers of telocytes were identified in ULM compared to adjacent myometrium tissues (Myo-F) and normal myometrium (Myo-N), indicating their increased cellular activity.
- Telocytes in ULM may play crucial roles in hormone sensing, supporting myocyte formation, and regulating signaling pathways, highlighting their importance in uterine health.
Article Abstract
Background: Telocytes are specialized interstitial tissue cell type. Our aim is to characterize telocytes in human uterine leiomyoma (ULM) and its adjacent myometrium (Myo-F) as well as normal myometrium (Myo-N).
Methods: ULMs and Myo-F tissues were taken from hysterectomy specimens done to treat symptomatic uterine fibroids ( = 20). Myo-N is isolated from hysterectomies done on ULM- free uteri for other benign indications ( = 15).Telocytes were detected using immunohistochemistry to detect c-Kit (CD-117), as a surface marker expressed on telocytes, and electron microscopic examination to identify telocytes characteristic ultrastructure. Cellular count and electron microscopic features of telocytes in each of the studied tissues were compared.
Results: Telocytes could be detected in ULMs, Myo-F and Myo-N using c-KIT immunostaining. Electron microscopy confirmed the presence of telocytes in the three types of tissues identifying their characteristic features including small triangular or fusiform cell bodies with extensive cellular prolongations. ULM telocytes showed ultrastructural features suggestive of high cellular activities. Cell counts of ULM telocytes (3.35 ± 0.39) were significantly higher ( value = 0.00039) than that of Myo-F (1.39 ± 0.13). Myo-N (2.6 ± 0.36) contained higher telocyte numbers than Myo-F (1.39 ± 0.13), but the difference did not reach statistical significance ( value = 0.19).
Conclusions: Telocytes are detected in higher numbers and activity in ULMs than Myo-F or Myo-N. In ULMs, telocytes can work as a hormonal sensors for stem cells, provide scaffold for newly formed myocytes, or control important downstream signaling pathways.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5693520 | PMC |
| http://dx.doi.org/10.1186/s40834-016-0022-5 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Cardiac cells and mesenchymal stem cells derived extracellular vesicles: a potential therapeutic strategy for myocardial infarction.
Front Cardiovasc Med
December 2024
Department of Cardiology, Affiliated Hospital of North Sichuan Medical College, Nanchong, China.
Despite improvements in clinical outcomes of acute myocardial infarction (AMI), mortality rates remain high, indicating the need for further understanding of the pathogenesis and developing more effective cardiac protection strategies. Extracellular vesicles (EVs) carry proteins and noncoding RNAs (ncRNAs) derived from different cardiac cell populations, mainly including cardiomyocytes, endothelial cells, endothelial progenitor cells, cardiac progenitor cells, cardiosphere-derived cells, immune cells, fibroblasts and cardiac telocytes have vital roles under both physiological and pathological process such as myocardial infarction (MI). The content of EVs can also indicate the status of their parental cells and serve as a biomarker for monitoring the risk of cardiac injury.
View Article and Find Full Text PDFVascular endothelial growth factor facilitates the effects of telocytes on tumor cell proliferation and migration.
Front Cell Dev Biol
November 2024
Liaoning Technology and Engineering Center for Tumor Immunology and Molecular Theranotics, Collaborative Innovation Center for Age-related Disease, Life Science Institute of Jinzhou Medical University, Jinzhou, China.
Background: Telocytes, recently recognized as interstitial cells with a diverse range of potential functions, have attracted considerable attention for their involvement in tumorigenesis. Nevertheless, owing to certain challenges in the isolation and cultivation of telocytes, the research on telocytes has advanced rather slowly. Therefore, it is imperative to study the role and mechanisms of telocytes in tumors.
View Article and Find Full Text PDFUnique insights into morphological characterization and functional adaptation of the scaly shank skin in aquatic and terrestrial birds.
Sci Rep
November 2024
Department of Anatomy and Embryology, Faculty of Veterinary Medicine, South Valley University, Qena, 83523, Egypt.
The avian skin is a vital barrier against external effects and undergoes modification to adapt to the different ecosystems. The current study focused on the comprehensive study of the scaly shank skin of aquatic birds, Egyptian Balady Duck (EBD) as well as terrestrial birds, Broad Breasted White Turkey (BBWT) via gross anatomy, histology, and scanning electron microscopy with ED-XRF analysis. The shank skin color was yellow to black in EBD and creamy-white in BBWT.
View Article and Find Full Text PDFNovel Insights Into the Ultrastructural and Immunofluorescence Characteristics of Limb Skin in the Red-Eared Slider Turtle (Trachemys scripta elegans).
Microsc Res Tech
November 2024
Faculty of Veterinary Medicine, Department of Anatomy and Embryology, Damanhour University, Damanhour, Egypt.
The red-eared slider turtle, a species facing environmental challenges and habitat loss, exhibits a complex skin architecture that is crucial for its adaptation and survival. Our study aims to provide a comprehensive characterization of the turtle's skin structure and to elucidate the distribution and localization of its various cellular components, with a focus on understanding the skin's role in adaptation and ecological interactions. To achieve these goals, we employed light microscopy, transmission electron microscopy (TEM), and comprehensive immunofluorescence using 10 specific antibodies.
View Article and Find Full Text PDFDescriptive embryological insights of the colorectum of quail embryos with concern to its functional morphology.
BMC Vet Res
November 2024
Department of Anatomy and Embryology, South Valley University, Qena, 83523, Egypt.
Background: Quail is an interesting emerging bird species gaining attention in developmental embryology research due to its small size, quick lifespan, and fast growth rate. These characteristics make quail an ideal model for examining the development of the gastrointestinal tract. Consequently, the embryonic development of the colorectum was conducted to provide a comprehensive understanding of its functions in digestion, absorption, and immunity.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!