AI Article Synopsis
- The study investigates neutrophil extracellular traps (NETs) production in pediatric leukemia patients, focusing on acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML) after chemotherapy.
- Results show that patients with AML had significantly lower neutrophil elastase activity and NETs formation compared to those with ALL, indicating a potential difference in immune response.
- Additionally, AML patients experienced more febrile neutropenia episodes and showed a trend towards higher rates of bacterial and fungal infections during the initial phases of treatment.
Article Abstract
Data on the production of neutrophil extracellular traps (NETs) in leukemia patients are scant. Phagocytosis, hydrogen peroxide, neutrophil elastase and myeloperoxidase enzymatic activity as well as NETs formation were studied in 10 pediatric acute lymphoblastic leukemia and 7 pediatric acute myeloid leukemia (AML) patients after induction chemotherapy. Median neutrophil elastase activity and NETs formation were lower in AML versus acute lymphoblastic leukemia (41% vs. 90%, P=0.005 and 51% vs. 94%, P=0.008, respectively). AML patients had more episodes of febrile neutropenia during the first 2 blocks of treatment (100% vs. 40%, P=0.011) and a trend for more invasive bacterial and fungal infections.
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| http://dx.doi.org/10.1097/MPH.0000000000001015 | DOI Listing |
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