A long-term inflammatory response can cause the development of nonalcoholic steatohepatitis (NASH), which is mainly caused by abnormal metabolism of lipids in the liver. Taiwanofungus salmonea and Grifola frondosa, which are valuable medicinal mushrooms in Taiwan and exhibit many beneficial bioactivities, are used to evaluate effects on immune regulation in Raw 264.7 cells and on NASH-related responses in Hep G2 cells. According to the results, the production of proinflammatory cytokines was effectively decreased, whereas the production of interleukin-10 was increased. Lipid accumulation and reactive oxygen species production also declined, and free glycerol was released. The expression of acetyl-CoA carboxylase, fatty acid synthase, and sterol regulatory element-binding protein 1c was decreased. These results indicate that T. salmonea and G. frondosa are capable of reducing inflammatory responses and ameliorating NASH, indicating their potential as hepatoprotective dietary supplements.
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Antrodia salmonea suppresses epithelial-mesenchymal transition/metastasis and Warburg effects by inhibiting Twist and HIF-1α expression in Twist-overexpressing head and neck squamous cell carcinoma cells.
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Department of Cosmeceutics, College of Pharmacy, China Medical University, Taichung, 406040, Taiwan; Department of Health and Nutrition Biotechnology, Asia University, Taichung, 413305, Taiwan; Chinese Medicine Research Center, China Medical University, Taichung, 404333, Taiwan; Research Center of Chinese Herbal Medicine, China Medical University, Taichung, 404333, Taiwan. Electronic address:
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Aim Of The Study: In this study, we investigated the metabolic reprogramming and anti-metastasis/epithelial-mesenchymal transition (EMT) effects of AS exposure in Twist-overexpressing head and neck squamous cell carcinoma (HNSCC, OECM-1 and FaDu-Twist) cells.
Materials And Methods: MTT assay, Western blot, migration/invasion assay, immunofluorescence, glucose uptake assay, lactate assay, oxygen consumption rate (OCR)/Extracellular acidification rate (ECAR) assay, Liquid Chromatography-Electrospray Ionization Tandem Mass Spectrometry (LC-ESI-MS), and qRT-PCR experimental techniques were used to evaluate the therapeutic potential of AS treatment in HNSCC cells.
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Institute of Nutrition, College of Health Care, China Medical University, Taichung 40402, Taiwan, ROC. Electronic address:
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Department of Health and Nutrition Biotechnology, Asia University, Taichung, 41354, Taiwan; Chinese Medicine Research Center, China Medical University, Taichung, 40402, Taiwan; Research Center of Chinese Herbal Medicine, China Medical University, Taichung, 40402, Taiwan; Department of Cosmeceutics, College of Pharmacy, China Medical University, Taichung, 40402, Taiwan. Electronic address:
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A traditional Chinese medicinal fungus, (AS), with antioxidant properties is familiar in Taiwan but anti-cancer activity of AS in human colon cancer is ambiguous. Hence, we explored the anti-cancer activity of AS in colon cancer cells. 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay revealed that AS showed a remarkable effect on cell viability in colon cancer cells; SW620, HCT116, and HT29.
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