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Preservation of Vascular Endothelial Function in Late-Onset Postmenopausal Women.
Circ Res
January 2025
Department of Integrative Physiology, University of Colorado Boulder (S.D., K.O.M., K.R.L., K.H.A., D.H.C., K.A.F., D.R.S., M.J.R.).
Background: Postmenopausal women (PMW) who complete menopause at a late age (55+ years) have lower cardiovascular disease risk than PMW who complete menopause at a normal age (45-54 years). However, the influence of late-onset menopause on vascular endothelial dysfunction is unknown. Moreover, the mechanisms by which a later age at menopause may modulate endothelial function remain to be determined.
View Article and Find Full Text PDFSingle-Virus Microscopy of Biochemical Events in Viral Entry.
JACS Au
January 2025
Department of Biomedical Engineering, University of Virginia, Box 800759, Charlottesville, Virginia 22908, United States.
Cell entry by enveloped viruses involves a set of multistep, multivalent interactions between viral and host proteins as well as manipulation of nanoscale membrane mechanics by these interacting partners. A mechanistic understanding of these events has been challenging due to the complex nature of the interactions and the event-to-event heterogeneity involved. Single-virus microscopy has emerged as a powerful technique to probe viral binding and fusion kinetics.
View Article and Find Full Text PDFEosinophils: old cells, new directions.
Front Med (Lausanne)
January 2025
Hospital Universitario de Gran Canaria Dr. Negrín, Respiratory Service, Las Palmas de Gran Canaria, Spain.
Eosinophils are polymorphonuclear cells that have progressively gained attention due to their involvement in multiple diseases and, more recently, in various homeostatic processes. Their well-known roles range from asthma and parasitic infections to less prevalent diseases such as eosinophilic granulomatosis with polyangiitis, eosinophilic esophagitis, and hypereosinophilic syndrome. In recent years, various biological therapies targeting these cells have been developed, altering the course of eosinophilic pathologies.
View Article and Find Full Text PDFTranscatheter Tricuspid Valve Replacement With EVOQUE and Mitral Valve Repair With PASCAL in One Procedure.
JACC Case Rep
January 2025
Department for Internal Medicine II, Cardiology, Medical University of Vienna, Vienna, Austria.
Mitral and tricuspid regurgitation, linked to high morbidity and mortality, are increasingly treated with interventional edge-to-edge repair, showing excellent results in favorable anatomy. Recently, interventional valve replacement strategies have emerged. We present a patient with severe dyspnea and leg edema who was diagnosed with severe mitral and torrential tricuspid regurgitation.
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