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scRNA + BCR-seq identifies proportions and characteristics of dual BCR B cells in the peritoneal cavity of mice and peripheral blood of healthy human donors across different ages.
Immun Ageing
December 2024
Department of Immunology, Center of Immuno-molecular Engineering, Innovation & Practice Base for Graduate Students Education, Zunyi Medical University, Zunyi, China.
The increased incidence of inflammatory diseases, infectious diseases, autoimmune disorders, and tumors in elderly individuals is closely associated with several well-established features of immunosenescence, including reduced B cell genesis and dampened immune responses. Recent studies have highlighted the critical role of dual receptor lymphocytes in tumors and autoimmune diseases. This study utilized shared data generated through scRNA-seq + scBCR-seq technology to investigate the presence of dual receptor-expressing B cells in the peritoneum of mouse and peripheral blood of healthy volunteers, and whether there are age-related differences in dual receptor B cell populations.
View Article and Find Full Text PDFCan rewards enhance creativity? Exploring the effects of real and hypothetical rewards on creative problem solving and neural mechanisms.
Behav Brain Funct
December 2024
School of Psychology, Northeast Normal University, 5268 Renmin Street, Changchun, 130024, Jilin, China.
Reward cues have long been considered to enhance creative performance; however, little is known about whether rewards can affect creative problem solving by manipulating states of flexibility and persistence. This study sought to elucidate the differential impacts of real versus hypothetical rewards on the creative process utilizing the Chinese compound remote association task. Behavioral analysis revealed a significantly enhanced solution rate and response times in scenarios involving real rewards, in contrast to those observed with hypothetical rewards.
View Article and Find Full Text PDFComparative study of the oral hygiene status of users of mefakia (traditional tooth cleaning method) and modern toothbrushes among patients at the Holy Bethel Dental Clinic in Addis Ababa, Ethiopia.
BDJ Open
December 2024
School of Public Health, College of Medicine and Health Sciences, Wollo University, Dessie, Ethiopia.
Background: Mefakia is a well-known traditional chewing wood used in Ethiopia to cleanse the mouth. Although mefakia is used in parallel with modern toothbrushes to improve oral hygiene, there is a gap in the literature regarding its comparative performance in removing plaque and maintaining good oral hygiene.
Objective: This study aimed to evaluate and compare the oral hygiene status of patients using mefakia and modern toothbrushes at the Holy Bethel Dental Clinic in Addis Ababa, Ethiopia.
The relationship between information literacy and online learning engagement: a moderated mediating model.
BMC Psychol
December 2024
Mental Health Education and Counseling Center, Nanchang Hangkong University, 696, Fenghe South Avenue, Nanchang, 330063, China.
Purpose: This study aims to examine how college students' information literacy affects their online learning engagement and what factors contribute to this relationship.
Method: The research adopted the method of cluster sampling to deliver a questionnaire survey to a sample of 1421 students' representative of four colleges. Information Literacy Scale, Online Learning Engagement Scale, Information Literacy Self-Efficacy Scale, and Psychological Resilience Scale were utilized in this study.
A cross-sectional study assessing customers' perception, satisfaction, and attitude toward e-pharmacy services in Saudi Arabia.
BMC Health Serv Res
December 2024
Clinical Pharmacy Department, College of Pharmacy, King Khalid University, Abha, Saudi Arabia.
Background: Electronic pharmacy (e-pharmacy) services are growing rapidly, offering increased accessibility, privacy, and value. Understanding e-pharmacy customer satisfaction, attitudes, and perceptions in Saudi Arabia is crucial for improving the services and enhancing health outcomes. This study aims to examine customers' perceptions, preferences, satisfaction, and experiences with electronic pharmacy services, including community pharmacy e-commerce.
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