AI Article Synopsis
- Btnl5 is a newly discovered member of the butyrophilin family that plays a role in immune regulation, though its specific functions and expression patterns are not fully understood.
- Btnl5 is primarily found in intestinal epithelial cells and acts as a negative regulator of the NF-κB pathway by inhibiting MyD88-mediated activation.
- It interacts with proteins like TRAF2 and transcription factor p65, preventing p65 from activating the NF-κB pathway and blocking its movement into the nucleus.
Article Abstract
Porcine butyrophilin-like 5 (Btnl5) is a novel member of the butyrophilin family, which consists of immune regulators. The expression pattern and the function of this gene remain unclear. In this study, Btnl5 is identified as a negative regulator of the NF-κB pathway. Our study indicates that Btnl5 is mainly expressed in intestinal epithelial cells (IECs) and expressed in membrane systems. Btnl5 inhibits MyD88-mediated activation of the NF-κB pathway. Btnl5 interacts with TNF receptor-associated factor 2 (TRAF2) and transcription factor p65. Besides, Btnl5 inhibits p65-mediated activation of the NF-κB pathway and inhibits nuclear translocation of p65. These results suggest that Btnl5 may inhibit NF-κB pathway through binding and interfere nuclear translocation of p65.
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| http://dx.doi.org/10.1016/j.gene.2017.11.070 | DOI Listing |
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