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Editorial Commentary: The Free Floating Disc Shaped Polycarbonate-Urethane Meniscal Implant Has High Reoperation Rates at 24 Months Follow-up.
Arthroscopy
January 2025
Fellowship Director Emeritus, Plano Orthopedic and Sports Medicine Center, Plano Texas.
A free-floating disc shaped polycarbonate-urethane ultra-high molecular weight polyethylene fiber reinforced medial compartment implant is designed for symptomatic postmedial meniscectomy syndrome. Because it is not sutured into place, an intact 2mm meniscus rim with intact anterior and posterior meniscal horns are required. In a recent 24-month follow-up study, only 64% of the original implants were retained.
View Article and Find Full Text PDFStandardization for Data Generation and Collection in the Dairy Industry: Addressing Challenges and Charting a Path Forward.
Animals (Basel)
January 2025
Zinpro Corporation, Eden-Prairie, MN 55344, USA.
Standards for data generation and collection are important for integration and for achieving data-driven actionable insights in dairy farming. Data integration and analysis are critical for advancing the dairy industry, enabling better decision-making, and improving operational efficiencies. This commentary paper discusses the challenges of and proposes pathways for standardizing data generation and collection based on insights from a multidisciplinary group of stakeholders.
View Article and Find Full Text PDFIntegrating New Approach Methodologies to Address Environmental Pancreatic Toxicity and Metabolic Disorders.
Biology (Basel)
January 2025
Center for Computational Toxicology and Exposure, US Environmental Protection Agency, Research Triangle Park, NC 27711, USA.
Advancing our understanding of pancreatic toxicity and metabolic disorders caused by environmental exposures requires innovative approaches. The pancreas, a vital organ for glucose regulation, is increasingly recognized as a target of harm from environmental chemicals and dietary factors. Traditional toxicological methods, while foundational, often fail to address the mechanistic complexities of pancreatic dysfunction, particularly under real-world conditions involving multiple exposures.
View Article and Find Full Text PDFElegant and Innovative Recoding Strategies for Advancing Vaccine Development.
Vaccines (Basel)
January 2025
Department of Veterinary Microbiology and Immunology, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, SK S7N 5E2, Canada.
Recoding strategies have emerged as a promising approach for developing safer and more effective vaccines by altering the genetic structure of microorganisms, such as viruses, without changing their proteins. This method enhances vaccine safety and efficacy while minimizing the risk of reversion to virulence. Recoding enhances the frequency of CpG dinucleotides, which in turn activates immune responses and ensures a strong attenuation of the pathogens.
View Article and Find Full Text PDFUnraveling the Invisible: Topological Data Analysis as the New Frontier in Radiology's Diagnostic Arsenal.
Tomography
January 2025
Department of Radiology, University of Padova, 35127 Padova, Italy.
This commentary examines Topological Data Analysis (TDA) in radiology imaging, highlighting its revolutionary potential in medical image interpretation. TDA, which is grounded in mathematical topology, provides novel insights into complex, high-dimensional radiological data through persistent homology and topological features. We explore TDA's applications across medical imaging domains, including tumor characterization, cardiovascular imaging, and COVID-19 detection, where it demonstrates 15-20% improvements over traditional methods.
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