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Effects of continuation electroconvulsive therapy on quality of life in elderly depressed patients: A randomized clinical trial. | LitMetric

AI Article Synopsis

  • A study compared the effectiveness of electroconvulsive therapy (ECT) combined with medications ("STABLE + PHARM" group) versus medications alone ("PHARM" group) in improving health-related quality of life (HRQOL) for elderly patients with major depressive disorder (MDD) after successful ECT treatment.
  • The research involved 120 participants aged over 60, where the "STABLE + PHARM" group received weekly ECT sessions alongside medications, while the "PHARM" group received only medications like venlafaxine and lithium.
  • Results showed significant improvements in both physical and mental health scores for the "STABLE + PHARM" group, suggesting that ongoing ECT could help prevent relapse and enhance overall

Article Abstract

We examined whether electroconvulsive therapy (ECT) plus medications ("STABLE + PHARM" group) had superior HRQOL compared with medications alone ("PHARM" group) as continuation strategy after successful acute right unilateral ECT for major depressive disorder (MDD). We hypothesized that scores from the Medical Outcomes Study Short Form-36 (SF-36) would be higher during continuation treatment in the "STABLE + PHARM" group versus the "PHARM" group. The overall study design was called "Prolonging Remission in Depressed Elderly" (PRIDE). Remitters to the acute course of ECT were re-consented to enter a 6 month RCT of "STABLE + PHARM" versus "PHARM". Measures of depressive symptoms and cognitive function were completed by blind raters; SF-36 measurements were patient self-report every 4 weeks. Participants were 120 patients >60 years old. Patients with dementia, schizophrenia, bipolar disorder, or substance abuse were excluded. The "PHARM" group received venlafaxine and lithium. The "STABLE + PHARM" received the same medications, plus 4 weekly outpatient ECT sessions, with additional ECT session as needed. Participants were mostly female (61.7%) with a mean age of 70.5 ± 7.2 years. "STABLE + PHARM" patients received 4.5 ± 2.5 ECT sessions during Phase 2. "STABLE + PHARM" group had 7 point advantage (3.5-10.4, 95% CI) for Physical Component Score of SF-36 (P < 0.0001), and 8.2 point advantage (4.2-12.2, 95% CI) for Mental Component Score (P < 0.0001). Additional ECT resulted in overall net health benefit. Consideration should be given to administration of additional ECT to prevent relapse during the continuation phase of treatment of MDD. CLINICAL TRIALS.GOV: NCT01028508.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5742556PMC
http://dx.doi.org/10.1016/j.jpsychires.2017.11.001DOI Listing

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