Most creatures on this planet possess an ability to anticipate upcoming events in the environment, courtesy of their circadian clocks. This allows them to prepare for those changes instead of being caught by surprise, which could mean the difference between life and death. In this SnapShot, we describe the basics of how the clock ticks.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.cell.2017.11.021 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Unfortunately, survivors of traumatic stress exposure (TSE) frequently develop adverse posttraumatic neuropsychiatric sequelae (APNS) such as chronic pain and stress/depressive symptoms. Increasing evidence indicates that there is a 'window of opportunity' following TSE in which therapeutic interventions are most effective against APNS, yet mechanisms accounting for this observation are poorly understood. Here, we aimed to better understand such mechanisms by generating snapshots of the transcriptional landscape in the early aftermath of TSE across tissues and time.
View Article and Find Full Text PDFQuantification of circadian rhythms in mammalian lung tissue snapshot data.
Sci Rep
July 2024
Charité Center for Basic Sciences, Institute for Theoretical Biology, Charité-Universitätsmedizin Berlin, Berlin, Germany.
Healthy mammalian cells have a circadian clock, a gene regulatory network that allows them to schedule their physiological processes to optimal times of the day. When healthy cells turn into cancer cells, the circadian clock often becomes cancer specifically disturbed, so there is an interest in the extraction of circadian features from gene expression data of cancer. This is challenging, as clinical gene expression samples of cancer are snapshot-like and the circadian clock is best examined using gene expression time series.
View Article and Find Full Text PDFAssessment and Management of Sleep Disturbance in Palliative Care Settings.
J Palliat Med
July 2024
School of Psychology, Faculty of Science, University of Sydney, Sydney, New South Wales, Australia.
Sleep disturbances, including insomnia, sleep-disordered breathing, and circadian rhythm disorders with potential consequences including excessive daytime somnolence and worsening fatigue, are prevalent yet largely under-measured and therefore under-managed problems in people receiving palliative care. This has the potential to negatively affect the person's functioning and quality of life. We aimed to review the current practice of assessment and management of sleep disturbances in people with life-limiting illnesses in Australian and New Zealand palliative care settings, and to define areas for improvement in assessment and management of sleep disturbances and further research.
View Article and Find Full Text PDFChronic Pallidal Local Field Potentials Are Associated With Dystonic Symptoms in Children.
Neuromodulation
April 2024
Division of Neurology, the Hospital for Sick Children, Toronto, Ontario, Canada; Department of Pediatrics, University of Toronto, Toronto, Ontario, Canada. Electronic address:
Article Synopsis
- Novel deep brain stimulation devices can record local field potentials (LFPs), which are key to understanding neuronal activity in patients with dystonia.
- A study with ten children found that LFP spectral power increased significantly during periods of dystonia, showing a 102% mean increase in symptomatic phases.
- The research also highlighted a circadian rhythm in the LFPs, indicating a correlation between LFP patterns and the timing of dystonic symptoms.
Whole-Body Mouse Fluxomic Analysis to Detect Metabolic Disruptions Associated with Microcephaly: Using C Isotopes.
Methods Mol Biol
November 2022
Department of Neurology, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Diverse metabolic disorders can disrupt brain growth, and analyzing metabolism in animal models of microcephaly may reveal new mechanisms of pathogenesis. The metabolism of functioning cells in a living organism is constantly changing in response to a changing environment, circadian rhythms, consumed food, drugs, progressing sicknesses, aging, and many other factors. Metabolic profiling can give important insights into the working machinery of the cell.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!