Chemical Diversity from a Chinese Marine Red Alga, Symphyocladia latiuscula.

This study describes an investigation into secondary metabolites that are produced by a marine red alga, , which was collected from coastal waters off Qingdao, China. A combination of normal, reversed phase, and gel chromatography was used to isolate six citric acid derived natural products, aconitates A-F (-), together with two known and ten new polybrominated phenols, symphyocladins C/D (), and symphyocladins H-Q (, and -), respectively. Structure elucidation was achieved by detailed spectroscopic (including X-ray crystallographic) analysis. We propose a plausible and convergent biosynthetic pathway involving a key quinone methide intermediate, linking aconitates and symphyocladins.