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Adult Outcomes of Childhood Wheezing Phenotypes Are Associated with Early-Life Factors.
J Pers Med
December 2024
Respiratory Biomedical Research Centre, University Hospital Southampton, Southampton SO16 6YD, UK.
While the phenotypic diversity of childhood wheezing is well described, the subsequent life course of such phenotypes and their adult outcomes remain poorly understood. We hypothesized that different childhood wheezing phenotypes have varying longitudinal outcomes at age 26. We sought to identify factors associated with wheezing persistence, clinical remission, and new onset in adulthood.
View Article and Find Full Text PDFRespiratory symptoms and pulmonary function in paint industry workers exposed to volatile organic compounds: A systematic review and meta-analysis.
PLoS One
December 2024
Department of Physiology, Sri Ramachandra Medical College & Research Institute, Sri Ramachandra Institute of Higher Education and Research(SRIHER), Chennai, Tamil Nadu, India.
Several epidemiological studies have examined the respiratory consequences of occupational exposure to volatile organic compounds (VOCs). However, their effects on paint industry workers in organised and unorganised occupational sectors vary. The present systematic review and meta-analysis aim at evaluating the respiratory symptoms and pulmonary function of paint industry workers from various occupational sectors exposed to VOCs.
View Article and Find Full Text PDFExposure Profiles for the Long-Term Use of Disinfectants and Cleaning Products and Asthma.
Allergy
December 2024
Institute and Clinic for Occupational, Social and Environmental Medicine, LMU University Hospital, LMU Munich, Munich, Germany.
Background: Using disinfectants and cleaning products (DCPs) at home and work is known to influence both the onset and course of asthma, but most epidemiological studies did not consider the multiplicity and correlations of exposures to DCPs. We aimed to identify exposure profiles for the long-term weekly use of DCPs by latent class analysis (LCA) and assess their associations with asthma.
Methods: LCA was conducted on data from 1143 young adults initially recruited in the German centers of Phase II of the International Study of Asthma and Allergies in Childhood (ISAAC) and followed up three times.
Clinical Implications of the Obstructive Pattern on Chest Radiography in Children Aged 3-59 Months With Severe Lower Respiratory Tract Infections.
Pediatr Pulmonol
December 2024
Department of Emergency Medicine, Ajou University School of Medicine, Suwon, Republic of Korea.
Objectives: To investigate the clinical implications of the obstructive pattern on plain chest radiography, defined as peribronchial cuffing or hyperinflation, in young children with severe lower respiratory tract infections (LRTIs).
Methods: We reviewed all children aged 3‒59 months with LRTIs who underwent radiography and polymerase chain reaction in a Korean emergency department from 2016 through 2020. The radiographs were read as consolidation, peribronchial cuffing, or hyperinflation, with each interrater reliability computed.
Pets and related allergens modify the association between early life DEHP exposure and respiratory outcomes in children.
Environ Res
December 2024
University of Toronto, Toronto, ON, Canada; The Hospital for Sick Children, Toronto, ON, Canada. Electronic address:
Introduction: Throughout the perinatal period children are exposed to complex mixtures, including indoor chemicals such as phthalates, and biological agents. However, few studies focus on interactions between early-life co-exposures to shed light on how co-exposures modify their individual effects. Therefore, our study aims to assess whether early-life exposure to pets and related biological agents, namely pet allergens and endotoxin, modifies the association between di-(2-ethylhexyl) phthalate (DEHP) and asthma and wheeze in preschoolers to gain insight into interactions.
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