The spleen is the largest immune organ in the human body and is also essential for red blood cell homeostasis and iron recycling. An average human spleen is approximately 10 centimetres in length and weighs 150g. Pathological conditions can result in the spleen weighing in excess of 2000g and extending over 30 centrimetres in length. This remarkable property of the spleen to expand is termed splenomegaly. Splenomegaly can occur as a physiological response to stress or as a chronic process that is often detrimental to the wellbeing of the individual. Here, we will discuss the normal function and physiology of the spleen, the pathophysiological bases of splenomegaly and the commonly available therapeutic options. Additionally we will address experimental systems to determine the regulatory mechanisms underlying splenomegaly.
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| http://dx.doi.org/10.1016/j.biocel.2017.11.011 | DOI Listing |
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Contribution of neuroimaging to the understanding of social cognition in epilepsy.
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Epileptology Unit Reference Center for Rare Epilepsies Department of Neurology AP-HP Pitié-Salpêtrière Hospital Paris France; Rehabilitation Unit AP-HP Pitié-Salpêtrière Hospital Paris France; Paris Brain Institute (ICM), Sorbonne-Université, Inserm U1127, CNRS 7225, Paris F-75013 France; Université Paris Sorbonne, Paris, France. Electronic address:
This narrative review aims to identify and summarize existing research to better understand the pathophysiological and neuroanatomical bases of social cognition deficits in people with epilepsy. The neuroanatomical basis of social cognition was primarily examined in healthy subjects. In healthy individuals, social cognition is supported by a complex network of interconnected brain regions.
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